ALOX15B Antibody - C-terminal region (OAAB05791)

Catalog No: OAAB05791

Size:400UL

Western blot analysis of ALOX15B Antibody (C-term) in CEM cell lysates (35ug/lane). ALOX15B (arrow) was detected using the purified Pab.

Formalin-fixed and paraffin-embedded human skin tissue reacted with PSMD13 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Host: Rabbit
• Application: IHC-P,WB
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This ALOX15B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 597-627 amino acids from the C-terminal region of human ALOX15B.
• Predicted Homology Based on Immunogen Sequence: Human
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Application Info: WB: 1:1000
  IHC-P: 1:50~100

Target Info

• Gene Symbol: ALOX15B
• Alias Symbols: 15-lipoxygenase 2, 15-LOX-2, 15-LOX-B, 15S-lipoxygenase, arachidonate 15-lipoxygenase 2, arachidonate 15-lipoxygenase type II, arachidonate 15-lipoxygenase, second type, arachidonate omega(6) lipoxygenase, linoleate 13-lipoxygenase 15-LOb, polyunsaturated fatty acid lipoxygenase ALOX15B.
• NCBI Gene Id: 247
• Protein Name: Arachidonate 15-lipoxygenase B|arachidonate 15-lipoxygenase B isoform a [Homo sapiens]|arachidonate 15-lipoxygenase B isoform b [Homo sapiens]|arachidonate 15-lipoxygenase B isoform d [Homo sapiens]
• Description of Target: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells.
• Uniprot ID: O15296
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/NP_001034219.1,NP_001034220.1,NP_001132.2
• Molecular Weight: 75857