ALOX12B Recombinant Protein (OPCD00141)

Catalog No: OPCD00141

ALOX12B Recombinant Protein (OPCD00141) using SDS-PAGE

ALOX12B Recombinant Protein (OPCD00141) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Glu389-Ile701
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 90%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Alox12b
• Gene Full Name: arachidonate 12-lipoxygenase, 12R type
• Alias Symbols: 12R-;12R-lipoxygenase;12R-LOX;Alo;Aloxe2;arachidonate 12-lipoxygenase, 12R-type;e-LO;e-LOX2;epidermis-type lipoxygenase 12;epidermis-type lipoxygenase 2.
• NCBI Gene Id: 11686
• Protein Name: Arachidonate 12-lipoxygenase, 12R-type
• Description of Target: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12R)-hydroperoxyeicosatetraenoic acid/(12R)-HPETE and minor stereoisomers. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins.
• Uniprot ID: O70582
• Protein Accession #: NP_033789.1
• Nucleotide Accession #: NM_009659.2
• Protein Size (# AA): Glu389~Ile701
• Molecular Weight: 37kDa