Catalog No: OPCD01256
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SKU
OPCD01256
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Datasheets/ManualsPrintable datasheet for OPCD01256
Product Info
Predicted Species ReactivityHuman
Product FormatLyophilized PBS, pH7.4, containing 0.01% Sarkosyl, 1mM DTT, 5% Trehalose and Proclin300.
HostE.coli
ConjugationUnconjugated
ApplicationSDS-PAGE, WB, ELISA, IP
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Phe352-Cys656
::Subcellular Location: Cytoplasm, cytosol. Membrane
Reconstitution and StorageReconstitute in ddH2O to the original concentration prior to lyophilization. If additional dilution is required, dilute further in the original base lyophilization buffer excluding stabilizers such as Sarkosyl, Proclin, Trehalose or Sucrose. Do not vortex. Store at 2-8C for one month. Aliquot and store at -80C for 12 months. Avoid repeated freeze/thaw cycles.
Concentration200 ug/mL (prior to lyoph)
Purity> 90%
SourceProkaryotic Expressed Recombinant
TagN-terminal His Tag
Gene SymbolALOX12
Gene Full Namearachidonate 12-lipoxygenase, 12S type
Alias SymbolsLOG12, 12-LOX, 12S-LOX
NCBI Gene Id239
Protein NameArachidonate 12-lipoxygenase, 12S-type
Description of TargetNon-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation.
Uniprot IDP18054
Protein Accession #NP_000688.2
Nucleotide Accession #NM_000697.2
Molecular Weight38 kDa
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