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AKT1 Antibody (OACA02419)

100 ug
$315.00
In Stock
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Predicted Species Reactivity:
Human
Product Format:
Liquid
Clonality:
Polyclonal
Isotype:
IgG
Host:
Rabbit
Application:
WB, IHC, CHIP
Reconstitution and Storage:
Store at 4C for up to one month. For long term storage, aliquot and store at -20C or -80C. Avoid freeze thaw cycles.
Replacement Item:
This antibody may replace item sc-135829, HPA002891
Immunogen:
Recombinant human RAC-alpha serine/threonine-protein kinase protein
Purification:
Caprylic Acid Ammonium Sulfate Precipitation purified
Predicted Homology Based on Immunogen Sequence:
Human
Datasheets/Manuals:
Printable datasheet for anti-AKT1 (OACA02419) antibody
Specificity:
Human
Formulation:
Provided in PBS, pH 7.4, 50% Glycerol, 0.03% Proclin 300
Target Reference:
[1] Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. Jones P.F., Jakubowicz T., Pitossi F.J., Maurer F., Hemmings B.A.Proc. Natl. Acad. Sci. U.S.A. 88:4171-4175 (1991)
Gene Symbol:
AKT1
Official Gene Full Name:
v-akt murine thymoma viral oncogene homolog 1
Alias Symbols:
AKT, PKB, RAC, CWS6, PRKBA, PKB-ALPHA, RAC-ALPHA
NCBI Gene Id:
207
Protein Name:
RAC-alpha serine/threonine-protein kinase
Description of Target:
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.
Swissprot Id:
P31749
Protein Accession #:
NP_001014431.1
Nucleotide Accession #:
NM_001014431.1
Protein Size (# AA):
480
Molecular Weight:
56 kDa
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express AKT1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express AKT1.

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