Catalog No: OPPA02072 (Formerly GWB-5E6128)
Size:2UG
Price: $75.00
SKU
OPPA02072
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AIF1 Protein (OPPA02072)

Datasheets/ManualsPrintable datasheet for OPPA02072
Product Info
Predicted Species ReactivityHuman
Product FormatSterile filtered and lyophilized from 0.5mg/ml in 20mM Tris buffer and 50mM NaCl pH-7.5.
HostE. Coli
ApplicationWB
Additional InformationSolubility: Add 0.2 ml of deionized water and let the lyophilized pellet dissolve completely.
::Product Introduction: Human AIF1 protein shares 98% homology/identity with that of rat. AIF1 is expressed in macrophages and neutrophils. The expression of AIF1 transcripts is upregulated by IFN-g in rat macrophages. AIF1 is expressed selectively in human macrophage-like cell lines, and in a subset of CD68(+) macrophages in the interstitial and perivascular spaces of human heart allografts. In quiescent cultured human vascular smooth muscle cells synthesis of AIF1 is induced by IFN-g, IL1b, and conditioned medium of T-cells. Overexpression of AIF1 in human VSMCs results in enhanced growth of these cells. AIF1 is expressed during apoptosis rat mammary gland and ventral prostate tissues. Allograft Inflammatory Factor 1 is expressed by several tumor-associated activated macrophages and microglial cells in rat and human gliomas. There is an evident relationship of AIF1-expressing activated macrophages and microglial cells with tumor malignancy in humans.
Product Description: The AIF1 Human Recombinant contains a total of 155 amino acids having a molecular Mass of 17.7kDa. The Human AIF1 is fused to a 9 amino acid long N-terminal FLAG tag.
Reconstitution and StorageFor long term, store lyophilized AIF1 at -20C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4C for a limited period of time; it does not show any change after two weeks at 4C. The lyophilized protein remains stable for 24 months when stored at -20C.
PurityGreater than 90% as determined by SDS PAGE.
Peptide SequenceMKHHHHHHASQTRDLQGGKAF ­GLLKAQQEERLDE ­INKQFLDDPKYSSDED ­LPSKLEGFKEKYMEF ­DLNGNGDIDIMSLKRMLEK ­LGVPKTHLELKKLI ­GEVSSGSGETFSYP ­DFLRMMLGKRSAIL ­KMILMYEEKAREKEK ­PTGPPAKKAISELP.
Gene SymbolAIF1
Alias SymbolsIBA1, IRT1, AIF-1, IRT-1
NCBI Gene Id199
Protein NameAllograft inflammatory factor 1
Description of TargetRecombinant Human Allograft Inflammatory Factor 1
Uniprot IDP55008
Protein Accession #NP_001614.3
Protein Size (# AA)Recombinant
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