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Catalog No: OPCD01208
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OPCD01208
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Datasheets/ManualsPrintable datasheet for AHR Recombinant Protein (OPCD01208)
Product Info
Predicted Species ReactivityMouse|Mus musculus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Val126-Gly385
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His and GST Tag
Gene SymbolAhr
Gene Full Namearyl-hydrocarbon receptor
Alias SymbolsA;Ah;ah receptor;Ahh;Ahre;aryl hydrocarbon receptor;bHLHe7;bHLHe76;dioxin receptor;In.
NCBI Gene Id11622
Protein NameAryl hydrocarbon receptor
Description of TargetLigand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409).
Uniprot IDP30561
Protein Accession #NP_038492.1
Nucleotide Accession #NM_013464.4
Protein Size (# AA)Val126~Gly385
Molecular Weight59kDa
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