AHR Recombinant Protein (OPCD01208)

Catalog No: OPCD01208

AHR Recombinant Protein (OPCD01208) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Ctrl (+), SDS-PAGE, WB
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Val126-Gly385
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His and GST Tag

Target Info

• Gene Symbol: Ahr
• Gene Full Name: aryl-hydrocarbon receptor
• Alias Symbols: A;Ah;ah receptor;Ahh;Ahre;aryl hydrocarbon receptor;bHLHe7;bHLHe76;dioxin receptor;In.
• NCBI Gene Id: 11622
• Protein Name: Aryl hydrocarbon receptor
• Description of Target: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409).
• Uniprot ID: P30561
• Protein Accession #: NP_038492.1
• Nucleotide Accession #: NM_013464.4
• Protein Size (# AA): Val126~Gly385
• Molecular Weight: 59kDa