AGR2 Antibody (OAEB01151)

Catalog No: OAEB01151 (Formerly GWB-20A582)

Size:100UG

OAEB01151 (0.01ug/ml) staining of Human Duodenum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Product Info

• Predicted Species Reactivity: Dog|Human|Mouse
• Product Format: Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
• Clonality: Polyclonal
• Host: Goat
• Application: WB
• Reconstitution and Storage: Aliquot and store at -20C. Minimize freezing and thawing.
• Immunogen: AGR2
• Purification: Ammonium Sulfate Precipitated; Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Dog: 91%; Human: 100%; Mouse: 91%; Pig: 91%
• Peptide Sequence: C-GAKKDTKDSRPK
• Concentration: 0.5 mg/ml
• Application Info: Peptide ELISA: antibody detection limit dilution 1:128000.
  Western Blot: Approx 17-18kDa band observed in Human Colon, Duodenum and Lung lysates (calculated MW of 20.0kDa according to NP_006399.1). Recommended concentration: up to 0.01ug/ml.
• Reference: * Innes HE, Liu D, Barraclough R, Davies MP, O'Neill PA, Platt-Higgins A, de Silva Rudland S, Sibson DR, Rudland PS.; Significance of the metastasis-inducing protein AGR2 for outcome in hormonally treated breast cancer patients.; Br J Cancer. 2006 Apr 10;94(7):1057-65.; Pubmed 16598187

Target Info

• Gene Symbol: Agr2|AGR2
• Gene Full Name: anterior gradient 2|anterior gradient 2, protein disulphide isomerase family member
• Alias Symbols: AG2;AG-2;Agr2h;anterior gradient 2 homolog;anterior gradient homolog 2;anterior gradient protein 2 homolog;epididymis secretory protein Li 116;Gob-;GOB-4;HAG-;HAG-2;HEL-S-116;HPC8;mAG-;mAG-2;PDIA17;protein disulfide isomerase family A, member 17;protein Gob-4;secreted cement gland homolog;secreted cement gland protein XAG-2 homolog;XAG-;XAG-2.
• NCBI Gene Id: 10551|23795
• Protein Name: Anterior gradient protein 2 homolog
• Description of Target: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression.
• Uniprot ID: O95994
• Protein Accession #: NP_006399.1
• Molecular Weight: 20