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- $55: Antibody & Protein in US
- $55 + $25/Kit in US
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| Datasheets/Manuals | Printable datasheet for ADRBK1 Antibody (OAAF00771) |
|---|
| Predicted Species Reactivity | Human|Mouse|Rat |
|---|---|
| Product Format | Liquid |
| Clonality | Polyclonal |
| Host | Rabbit |
| Application | Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin |
| Reconstitution and Storage | -20°C |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GRK2. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Specificity | GRK2 antibody detects endogenous levels of total GRK2 protein. |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Dilution | The optimal working dilution should be determined by the end user. |
| Application Info | IHC: 1:50~1:100; ELISA: 1:1000 |
| Reference | Aarti N. Desai, J. Pharmacol. Exp. Ther., Jun 2006; 317: 1027 - 1035. John A. Gray, Mol. Pharmacol., Nov 2001; 60: 1020. Anne Vroon, J. Leukoc. Biol., May 2004; 75: 901 - 909. R. J. Hughes, Am J Physiol Cell Physiol, Mar 1996; 270: C885 - C |
| Gene Symbol | GRK2 |
|---|---|
| Gene Full Name | G protein-coupled receptor kinase 2 |
| Alias Symbols | ADRBK1;adrenergic beta receptor kinase 1;BARK1;beta-adrenergic receptor kinase 1;beta-ARK-1;BETA-ARK1;G-protein coupled receptor kinase 2. |
| NCBI Gene Id | 156 |
| Protein Name | Beta-adrenergic receptor kinase 1 |
| Description of Target | Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). |
| Uniprot ID | P25098 |
| Protein Accession # | NP_001610.2 |
| Molecular Weight | 79 kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "ADRBK1 Antibody (OAAF00771)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Mouse|Rat".
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How long will it take to receive "ADRBK1 Antibody (OAAF00771)"?
This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".
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What buffer format is "ADRBK1 Antibody (OAAF00771)" provided in?
This item is provided in "Liquid".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "ADRBK1 Antibody (OAAF00771)"?
This target may also be called "ADRBK1;adrenergic beta receptor kinase 1;BARK1;beta-adrenergic receptor kinase 1;beta-ARK-1;BETA-ARK1;G-protein coupled receptor kinase 2." in publications.
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What is the shipping cost for "ADRBK1 Antibody (OAAF00771)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "ADRBK1 Antibody (OAAF00771)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "ADRBK1 Antibody (OAAF00771)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "79 kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "ADRBK1 Antibody (OAAF00771)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "GRK2"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "GRK2"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "GRK2"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "GRK2"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "GRK2"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "GRK2"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
