ADNP Antibody - N-terminal region (ARP39186_P050)

Catalog No: ARP39186_P050

WB Suggested Anti-ADNP Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: Human brain

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ADNP
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%
• Peptide Sequence: Synthetic peptide located within the following region: EDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQDYRTKPFCCSACPFSSKF
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-ADNP (ARP39186_P050) antibody is Catalog # AAP39186 (Previous Catalog # AAPP21291)
• Reference: Mandel,S. (2007) J. Biol. Chem. 282 (47), 34448-34456

Target Info

• Gene Symbol: ADNP
• Gene Full Name: Activity-dependent neuroprotector homeobox
• Alias Symbols: ADNP1, HVDAS, MRD28
• NCBI Gene Id: 23394
• Protein Name: Activity-dependent neuroprotector homeobox protein
• Description of Target: Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. ADNP is a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. It contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. It is also upregulated in normal proliferative tissues. Finally, ADNP may increase the viability of certain cell types through modulation of p53 activity.Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described.
• Uniprot ID: Q9H2P0
• Protein Accession #: NP_056154
• Nucleotide Accession #: NM_015339
• Protein Size (# AA): 1102
• Molecular Weight: 124kDa
• Protein Interactions: UBC; SUMO2; EED; RNF2; BMI1; HDAC1; HDAC11; MYC; CDC27; CBX5; PHGDH; RRS1; EBNA1BP2; SAP18; NFIA; SEPT2; EMD; SIRT7; CBX3; CBX1; MAP1LC3B; ARID1A; SMARCC2; SMARCA4;