ADCY5/6 Antibody (OAAF02815)

Catalog No: OAAF02815 (Formerly GWB-ASE004)

Size:100 ug

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ADCY5/6 Antibody. The picture on the right is treated with the synthesized peptide.

Immunofluorescence analysis of HeLa cells, using ADCY5/6 Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Paraffin
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human ADCY5/6.
• Purification: The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
• Specificity: ADCY5/6 antibody detects endogenous levels of total ADCY5/6 protein.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: IHC: 1:50~1:100; IF: 1:100~1:500; ELISA: 1:20000
• Reference: Wicker R., Biochim. Biophys. Acta 1493:279-283(2000).
  Ishikawa K., DNA Res. 4:307-313(1997).
  Nakajima D., DNA Res. 9:99-106(2002).

Target Info

• Gene Symbol: ADCY5|ADCY6
• Gene Full Name: adenylate cyclase 5|adenylate cyclase 6
• Alias Symbols: AC5;AC6;adenylate cyclase type 5;adenylate cyclase type 6;adenylate cyclase type V;adenylate cyclase type VI;adenylyl cyclase 5;Adenylyl cyclase 6;ATP pyrophosphate-lyase 5;ATP pyrophosphate-lyase 6;ca(2+)-inhibitable adenylyl cyclase;epididymis secretory sperm binding protein;FDFM;LCCS8.
• NCBI Gene Id: 111|112
• Protein Name: Adenylate cyclase type 5|Adenylate cyclase type 6
• Description of Target: Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:17916776, PubMed:17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol (PubMed:17916776). Contributes to bone cell responses to mechanical stimuli (By similarity).|Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569).
• Uniprot ID: O43306|O95622
• Protein Accession #: NP_001186571.1
• Molecular Weight: 130 kDa