ADAMTS4 Polyclonal Antibody (OABB00433)
|Predicted Species Reactivity||Human, Mouse, Rat|
|Additional Information||Content: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3|
|::||Background: ADAMTS4, A disintegrin and metalloproteinase with thrombospondin motifs 4 is an enzyme that in humans is encoded by the ADAMTS4 gene. ADAMTS4 is a member of the large ADAMTS family of zinc-dependent proteases. The human ADAMTS4 gene is mapped to chromosome 1 by somatic cell hybrid analysis. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.|
|Reconstitution and Storage||0.2ml of distilled water will yield a concentration of 500ug/ml. At -20C for one year. After reconstitution, at 4C for one month. It can
also be aliquotted and stored frozen at -20C for a longer time.
Avoid repeated freezing and thawing.
|Replacement Item||This antibody may replace item sc-16533 from Santa Cruz Biotechnology.|
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminal ofhuman ADAMTS4, different from the related rat and mouse sequencesby three amino acids.|
|Purification||Immunogen affinity purified.|
|Predicted Homology Based on Immunogen Sequence||Human; Mouse; Rat|
|Datasheets/Manuals||Printable datasheet for OABB00433|
|Target Reference||1. Hurskainen, T. L., Hirohata, S., Seldin, M. F., Apte, S. S.ADAM-TS5, ADAM-TS6, and ADAM-TS7,
novel members of a new family of zinc metalloproteases: general features and genomic distribution
of the ADAM-TS family.J. Biol. Chem. 274: 25555-25563, 1999.
2. Tang, B. L., Hong, W.ADAMTS: a novel family of proteases with an ADAM protease domain and
thrombospondin 1 repeats.FEBS Lett. 445: 223-225, 1999.
3. Tortorella, M. D., Burn, T. C., Pratta, M. A., Abbaszade, I., Hollis, J. M., Liu, R., Rosenfeld, S. A.,
Copeland, R. A., Decicco, C. P., Wynn, R., Rockwell, A., Yang, F., and 16 others.Purification and
cloning of aggrecanase-1: a member of the ADAMTS family of proteins.Science 284: 1664-1666,
|NCBI Gene Id||66015|
|Protein Name||A disintegrin and metalloproteinase with thrombospondin motifs 4|
|Tissue Tool||Find tissues and cell lines supported by DNA array analysis to express Adamts4.|
|RNA Seq||Find tissues and cell lines supported by RNA-seq analysis to express Adamts4.|
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