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ADAM19 Antibody - N-terminal region (ARP49780_P050)

100 ul
$319.00
In Stock
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Conjugation Options

ARP49780_P050-FITC Conjugated

ARP49780_P050-HRP Conjugated

ARP49780_P050-Biotin Conjugated

Gene Symbol:
ADAM19
Official Gene Full Name:
ADAM metallopeptidase domain 19
NCBI Gene Id:
8728
Protein Name:
Disintegrin and metalloproteinase domain-containing protein 19
Swissprot Id:
Q9H013
Protein Accession #:
NP_075525
Nucleotide Accession #:
NM_023038
Alias Symbols:
FKSG34, MADDAM, MLTNB
Replacement Item:
This antibody may replace item sc-25985 from Santa Cruz Biotechnology.
Description of Target:
ADAM19 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. Alternative splicing results in two transcript variants.This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. Alternative splicing results in two transcript variants.
Protein Size (# AA):
956
Molecular Weight:
82kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express ADAM19.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express ADAM19.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human ADAM19
Predicted Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Tested Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 93%; Zebrafish: 93%
Complete computational species homology data:
Anti-ADAM19 (ARP49780_P050)
Peptide Sequence:
Synthetic peptide located within the following region: VADYLEFQKNRRDQDATKHKLIEIANYVDKFYRSLNIRIALVGLEVWTHG
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
UBC; TNFSF11; COPB1; NRG1; FURIN; A2M; ABI2; SH3GL2; ESF1;
Blocking Peptide:
For anti-ADAM19 (ARP49780_P050) antibody is Catalog # AAP49780 (Previous Catalog # AAPS27503)
Datasheets/Manuals:
Printable datasheet for anti-ADAM19 (ARP49780_P050) antibody
Target Reference:
Tanabe,C., (2007) Biochem. Biophys. Res. Commun. 352 (1), 111-117
Publications:

Marballi, K., Cruz, D., Thompson, P. & Walss-Bass, C. Differential neuregulin 1 cleavage in the prefrontal cortex and hippocampus in schizophrenia and bipolar disorder: preliminary findings. PLoS One 7, e36431 (2012). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish 22590542

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