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Catalog No: ARP46370_P050
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ARP46370_P050
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Datasheets/ManualsPrintable datasheet for anti-ADAM15 (ARP46370_P050) antibody
Product Info
Tested Species ReactivityHuman, Mouse
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationIHC, WB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human ADAM15
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 86%; Dog: 79%; Guinea Pig: 79%; Horse: 85%; Human: 100%; Mouse: 100%; Pig: 85%; Rabbit: 79%; Rat: 100%
Peptide SequenceSynthetic peptide located within the following region: QPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQ
Concentration0.5 mg/ml
Blocking PeptideFor anti-ADAM15 (ARP46370_P050) antibody is Catalog # AAP46370 (Previous Catalog # AAPS18101)
ReferenceZhong,J.L., (2008) Mol. Cancer Res. 6 (3), 383-394
Gene SymbolADAM15
Gene Full NameADAM metallopeptidase domain 15
Alias SymbolsMDC15
NCBI Gene Id8751
Protein NameDisintegrin and metalloproteinase domain-containing protein 15
Description of TargetADAM15 is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling.The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
Uniprot IDQ71S69
Protein Accession #NP_997079
Nucleotide Accession #NM_207196
Protein Size (# AA)862
Molecular Weight70kDa
Protein InteractionsBANP; NUP62; RBPMS; UBC; SP4; FHL3; FBXO6; SH3PXD2A; SRC; PTK6; MAPK3; MAPK1; NCK1; GRB2; SNX30; SH3RF3; SNX9; SH3GLB1; PACSIN3; ARHGEF6; ARHGEF7; SORBS2; YES1; NPHP1; LYN; LCK; HCK; FYN; SH3D19; SH3RF1; SORBS3; SNX33; SORBS1; TRIP13; SH3GL2; ABL1; MAD2L1
  1. What is the species homology for "ADAM15 Antibody - middle region (ARP46370_P050)"?

    The tested species reactivity for this item is "Human, Mouse". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit".

  2. How long will it take to receive "ADAM15 Antibody - middle region (ARP46370_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "ADAM15 Antibody - middle region (ARP46370_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "ADAM15 Antibody - middle region (ARP46370_P050)"?

    This target may also be called "MDC15" in publications.

  5. What is the shipping cost for "ADAM15 Antibody - middle region (ARP46370_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "ADAM15 Antibody - middle region (ARP46370_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "ADAM15 Antibody - middle region (ARP46370_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "70kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "ADAM15 Antibody - middle region (ARP46370_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "ADAM15"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "ADAM15"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "ADAM15"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "ADAM15"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "ADAM15"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "ADAM15"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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