ADAM10 Recombinant Protein (OPCD01079)

Catalog No: OPCD01079

ADAM10 Recombinant Protein (OPCD01079) using SDS-PAGE

ADAM10 Recombinant Protein (OPCD01079) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Rat|Rattus norvegicus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Thr218-Asp445
  Subcellular Location: Membrane; Single-pass type I membrane prote
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Adam10
• Gene Full Name: ADAM metallopeptidase domain 10
• Alias Symbols: a disintegrin and metallopeptidase domain 10;a disintegrin and metalloprotease domain 10;ADAM 10;disintegrin and metalloproteinase domain-containing protein 10;kuzbanian protein homolog;MADM;mammalian disintegrin-metalloprotease;RGD1566370.
• NCBI Gene Id: 29650
• Protein Name: Disintegrin and metalloproteinase domain-containing protein 10
• Description of Target: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.
• Uniprot ID: Q10743
• Protein Size (# AA): Thr218~Asp445
• Molecular Weight: 30kDa