ADAM10 Antibody - middle region (OAGA02442)

Catalog No: OAGA02442

Size:100 ul

Sample (30 ug of whole cell lysate)
A: THP-1
7.5% SDS PAGE
OAGA02442 diluted at 1:1000

Immunohistochemical analysis of paraffin-embedded Lung Papillary Adenocarcinoma, using ADAM10 (OAGA02442) antibody at 1:250 dilution.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid.0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: IHC-P, WB
• Reconstitution and Storage: Store as a concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze/thaw cycles.
• Immunogen: Recombinant protein encompassing a sequence within the center region of human ADAM10. The exact sequence is proprietary.
• Purification: Purified by antigen-affinity chromatography.
• Concentration: Varies by lot. See vial for concentration.
• Application Info: WB 1:500~3000
  IHC-P 1:100~1000
• Publications:

  Sogorb-Esteve, A., García-Ayllón, M., Gobom, J., Alom, J., Zetterberg, H., Blennow, K. and Sáez-Valero, J. Levels of ADAM10 are reduced in Alzheimer’s disease CSF. J Neuroinflammation. 15, 213 (2018). 30045733

  α-Secretase nonsense mutation (ADAM10 Tyr167*) in familial Alzheimer's disease. Alzheimers Res Ther. 12, 139 (2020). 33129344

Target Info

• Gene Symbol: ADAM10
• Gene Full Name: ADAM metallopeptidase domain 10
• Alias Symbols: RAK, kuz, AD10, AD18, MADM, CD156c, CDw156, HsT18717
• NCBI Gene Id: 102
• Description of Target: Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin.
• Uniprot ID: O14672
• Molecular Weight: 84 kDa