ACVRL1 Antibody (OAAF02253)

Catalog No: OAAF02253 (Formerly GWB-ASD501)

Size:100 ug

Western blot analysis of extracts from K562 cells, using ACVL1 Antibody. The lane on the right is treated with the synthesized peptide.

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using ACVL1 Antibody. The picture on the right is treated with the synthesized peptide.

Immunofluorescence analysis of HeLa cells, using ACVL1 Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid in PBS (without Mg²⁺ and Ca²⁺) pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human ACVL1.
• Purification: The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
• Concentration: 1 mg/ml
• Specificity: ACVL1 antibody detects endogenous levels of total ACVL1 protein.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: WB: 1:500~1000
  IHC: 1:50~100
  IF: 1:100~500
  ELISA: 1:20000
• Reference: ten Dijke P., Oncogene 8:2879-2887(1993).
  Attisano L., Cell 75:671-680(1993).
  Berg J.N., Am. J. Hum. Genet. 61:60-67(1997).

Target Info

• Gene Symbol: ACVRL1
• Gene Full Name: activin A receptor like type 1
• Alias Symbols: activin A receptor type II-like 1;activin A receptor type IL;activin A receptor, type II-like kinase 1;Activin receptor-like kinase 1;ACVRLK1;ALK1;ALK-1;HHT;HHT2;ORW2;serine/threonine-protein kinase receptor R3;SKR3;TGF-B superfamily receptor type I;TSR-I.
• NCBI Gene Id: 94
• Protein Name: Serine/threonine-protein kinase receptor R3
• Description of Target: Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.
• Uniprot ID: P37023
• Protein Accession #: NP_000011.2
• Molecular Weight: 56 kDa