ACVRL1 Antibody - N-terminal region (ARP44199_P050)

Catalog No: ARP44199_P050

WB Suggested Anti-ACVRL1 Antibody Titration: 0.2-1 ug/ml
Positive Control: Jurkat cell lysate

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Dog, Horse, Pig
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ACVRL1
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Dog: 100%; Horse: 93%; Human: 100%; Mouse: 92%; Pig: 93%; Rat: 92%
• Peptide Sequence: Synthetic peptide located within the following region: SPHCKGPTCRGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPTEFVNH
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-ACVRL1 (ARP44199_P050) antibody is Catalog # AAP44199 (Previous Catalog # AAPP11975)
• Reference: Brakensiek,K., (er) Clin. Genet. (2008) In press

Target Info

• Gene Symbol: ACVRL1
• Gene Full Name: Activin A receptor type II-like 1
• Alias Symbols: HHT, ALK1, HHT2, ORW2, SKR3, ALK-1, TSR-I, ACVRLK1
• NCBI Gene Id: 94
• Protein Name: Serine/threonine-protein kinase receptor R3
• Description of Target: ACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. ACVRL1, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
• Uniprot ID: P37023
• Protein Accession #: NP_000011
• Nucleotide Accession #: NM_000020
• Protein Size (# AA): 503
• Molecular Weight: 55kDa
• Protein Interactions: TGFBR1; TGFB1; INHBA; SMAD1; PEG10; NR1H2; FKBP1A; CSNK2B; ENG; BAMBI; HSP90AA1; IGSF1; TSC22D1; SNX6; TGFBRAP1; XIAP; TGFB3; TGFBR2; ACVR2A;