ACTN2 Antibody - N-terminal region (OASG00186)

Catalog No: OASG00186

Size:100 uL

Western Blot using HepG2

Western Blot using HuvEc, MCF7, PC-12

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC, IF
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from the N-terminal region of human Actinin- Alpha2/3. Location: 1-80aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Specificity: Actinin- Alpha2/3 Polyclonal Antibody detects endogenous levels of Actinin- Alpha2/3 protein.
• Application Info: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000;

Target Info

• Gene Symbol: ACTN2, ACTN3
• Gene Full Name: actinin, alpha 2
• Alias Symbols: MPD6, CMH23, CMD1AA, MYOCOZ
• NCBI Gene Id: 88; 89; 11472; 11472;
• Description of Target: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.
• Uniprot ID: P35609, Q08043, Q9JI91, O88990
• Molecular Weight: 103 kDa