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ACTL6A Antibody (OACA02417)

100 ul
$315.00
In Stock
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Predicted Species Reactivity:
Human
Product Format:
Liquid
Clonality:
Polyclonal
Isotype:
IgG
Host:
Rabbit
Application:
WB, IHC, CHIP
Reconstitution and Storage:
Store at 4C for up to one month. For long term storage, aliquot and store at -20C or -80C. Avoid freeze thaw cycles.
Replacement Item:
This antibody may replace item sc-118664 from Santa Cruz Biotechnology.
Immunogen:
Recombinant human Actin-like protein 6A protein(1-280aa)
Purification:
Antigen Affinity Purified
Predicted Homology Based on Immunogen Sequence:
Human, Mouse
Datasheets/Manuals:
Printable datasheet for anti-ACTL6A (OACA02417) antibody
Specificity:
Human
Formulation:
Provided in PBS, pH 7.3, 50% Glycerol, 0.02% Sodium Azide
Application Data:
WB:1:500-5000, IHC:1:20-1:200
Target Reference:
[1] N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454 (2012).
[2] Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. Chen L., Cai Y., Jin J., Florens L., Swanson S.K., Washburn M.P., Conaway J.W., Conaway R.C.J. Biol. Chem. 286:11283-11289 (2011).
[3] Initial characterization of the human central proteome. Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17 (2011).
Gene Symbol:
ACTL6A
Official Gene Full Name:
actin like 6A
Alias Symbols:
Arp4, ACTL6, BAF53A, INO80K, ARPN-BETA
NCBI Gene Id:
86
Protein Name:
actin-like protein 6A
Description of Target:
This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.
Swissprot Id:
O96019
Protein Accession #:
NP_004292.1
Nucleotide Accession #:
NM_004301.4
Protein Size (# AA):
429
Molecular Weight:
47 kDa
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express ACTL6A.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express ACTL6A.

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