ACTL6A Antibody (OAAL00004)

Catalog No: OAAL00004

Size:100UG

Western Blot analysis of ACTL6A expression in transfected 293T cell line by ACTL6A monoclonal antibody (M10), clone 3C4.
Lane 1: ACTL6A transfected lysate(47.5 KDa).
Lane 2: Non-transfected lysate.

Detection limit for recombinant GST tagged ACTL6A is approximately 0.3ng/ml as a capture antibody.

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid
• Clonality: Monoclonal
• Clone: 3C4
• Isotype: IgG1 Kappa
• Host: Mouse
• Application: Enzyme-linked immunosorbent assay|Western blot
• Reconstitution and Storage: Store at -20C or lower. Aliquot to avoid repeated freezing and thawing.
• Immunogen: ACTL6A (NP_817126, 1 a.a. ~ 80 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Peptide Sequence: MVVERDDGSTLMEIDGDKGKQGGPTYYIDTNALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPVLM
• Formulation: In 1x PBS, pH 7.4

Target Info

• Gene Symbol: ACTL6A
• Gene Full Name: actin like 6A
• Alias Symbols: 53 kDa BRG1-associated factor A;actin-like protein 6A;actin-related protein 4;actin-related protein Baf53a;ACTL6;Arp4;arpNbeta;ARPN-BETA;BAF complex 53 kDa subunit;BAF53;BAF53A;BRG1-associated factor 53A;hArpN beta;INO80 complex subunit K;INO80K;SMARCN1.
• NCBI Gene Id: 86
• Protein Name: actin-like protein 6A isoform 2 [Homo sapiens]|Homo sapiens actin like 6A (ACTL6A), transcript variant 2, mRNA
• Description of Target: This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/NP_817126
• Nucleotide Accession #: https://www.ncbi.nlm.nih.gov/nuccore/NM_177989