Size:100 ul
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ARP56301_P050
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Conjugation Options

ARP56301_P050-FITC Conjugated

ARP56301_P050-HRP Conjugated

ARP56301_P050-Biotin Conjugated

ACO2 Antibody - N-terminal region (ARP56301_P050)

Catalog#: ARP56301_P050
Domestic: within 1-2 days delivery | International: 1-2 days
More Information
Tested Species Reactivity Human, Rat
Predicted Species Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality Polyclonal
Host Rabbit
Application WB
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-130677 from Santa Cruz Biotechnology.
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human ACO2
Purification Affinity Purified
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 86%
Complete computational species homology data Anti-ACO2 (ARP56301_P050)
Peptide Sequence Synthetic peptide located within the following region: LQFISSGLSKVAVPSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATA
Concentration Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide For anti-ACO2 (ARP56301_P050) antibody is Catalog # AAP56301 (Previous Catalog # AAPP34417)
Datasheets/Manuals Printable datasheet for anti-ACO2 (ARP56301_P050) antibody
Sample Type Confirmation

ACO2 is strongly supported by BioGPS gene expression data to be expressed in 721_B

Target Reference Yu,Z., (2006) Prostate 66 (10), 1061-1069
Publications

Freund, D. M., Prenni, J. E. & Curthoys, N. P. Response of the mitochondrial proteome of rat renal proximal convoluted tubules to chronic metabolic acidosis. Am. J. Physiol. Renal Physiol. 304, F145-55 (2013). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast 23136003

Schauer, K. L., Freund, D. M., Prenni, J. E. & Curthoys, N. P. Proteomic profiling and pathway analysis of the response of rat renal proximal convoluted tubules to metabolic acidosis. Am. J. Physiol. Renal Physiol. 305, F628-40 (2013). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast 23804448

Gene Symbol ACO2
Official Gene Full Name Aconitase 2, mitochondrial
Alias Symbols ACONM, MGC20605, MGC33908
NCBI Gene Id 50
Protein Name Aconitate hydratase, mitochondrial
Description of Target ACO2 belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Swissprot Id Q99798
Protein Accession # NP_001089
Nucleotide Accession # NM_001098
Protein Size (# AA) 780
Molecular Weight 82kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express ACO2.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express ACO2.
Protein Interactions SUMO2; UBC; SUMO1; NEDD8; MDM2; ASB9; VCAM1; ITGA4; AK3; SIN3A; ACAA2; APP; ACAT1; ATXN1L; SUMO4; PSMD4; SRRM2;
  1. What is the species homology for "ACO2 Antibody - N-terminal region (ARP56301_P050)"?

    The tested species reactivity for this item is "Human, Rat". This antibody is predicted to have homology to "Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast".

  2. How long will it take to receive "ACO2 Antibody - N-terminal region (ARP56301_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "ACO2 Antibody - N-terminal region (ARP56301_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "ACO2 Antibody - N-terminal region (ARP56301_P050)"?

    This target may also be called "ACONM, MGC20605, MGC33908" in publications.

  5. What is the shipping cost for "ACO2 Antibody - N-terminal region (ARP56301_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "ACO2 Antibody - N-terminal region (ARP56301_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "ACO2 Antibody - N-terminal region (ARP56301_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "82kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "ACO2 Antibody - N-terminal region (ARP56301_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "ACO2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "ACO2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "ACO2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "ACO2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "ACO2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "ACO2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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