Catalog No: OASG00647
Size:100 uL
Price: $239.00
SKU
OASG00647
Availability: Domestic: within 1 week delivery | International: 1 week
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ACLY Antibody (Phospho-Ser455) (OASG00647)

Datasheets/ManualsPrintable datasheet for anti-ACLY (OASG00647) antibody
Product Info
Predicted Species ReactivityHuman, Mouse, Rat, Monkey
Product FormatLiquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ApplicationWB, IHC, ELISA
Additional InformationCellular Localization: Cytoplasm.
Reconstitution and StorageStore at -20°C. Avoid repeated freeze/thaw cycles.
ImmunogenSynthesized peptide derived between 390-470 aa from human ATP-citrate synthase around the phosphorylation site of S455.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration1 mg/ml
Target Post-Translational ModificationISGylated. Acetylated at Lys-540, Lys-546 and Lys-554 by KAT2B/PCAF. Acetylation is promoted by glucose and stabilizes the protein, probably by preventing ubiquitination at the same sites. Acetylation promotes de novo lipid synthesis. Deacetylated by SIRT2. Ubiquitinated at Lys-540, Lys-546 and Lys-554 by UBR4, leading to its degradation. Ubiquitination is probably inhibited by acetylation at same site (Probable).
SpecificityPhospho-ATP-citrate synthase (S455) Polyclonal Antibody detects endogenous levels of ATP-citrate synthase protein only when phosphorylated at S455.
Application InfoWB: 1:500~2000
IHC: 1:100~300
ELISA: 1:10000
Optimal dilutions should be determined by the end user.
Publications

Modulation of matrix metabolism by ATP-citrate lyase in articular chondrocytes. J Biol Chem. 293, 12259-12270 (2018). 29929979

Gene SymbolACLY
Gene Full NameATP citrate lyase
Alias SymbolsACL, ATPCL, CLATP
NCBI Gene Id47
Description of TargetATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.
Uniprot IDP53396, Q91V92, P16638
Molecular Weight125 kDa
  1. What is the species homology for "ACLY Antibody (Phospho-Ser455) (OASG00647)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat, Monkey".

  2. How long will it take to receive "ACLY Antibody (Phospho-Ser455) (OASG00647)"?

    This item is available "Domestic: within 1 week delivery | International: 1 week".

  3. What buffer format is "ACLY Antibody (Phospho-Ser455) (OASG00647)" provided in?

    This item is provided in "Liquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "ACLY Antibody (Phospho-Ser455) (OASG00647)"?

    This target may also be called "ACL, ATPCL, CLATP" in publications.

  5. What is the shipping cost for "ACLY Antibody (Phospho-Ser455) (OASG00647)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "ACLY Antibody (Phospho-Ser455) (OASG00647)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "ACLY Antibody (Phospho-Ser455) (OASG00647)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "125 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "ACLY Antibody (Phospho-Ser455) (OASG00647)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "ACLY"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "ACLY"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "ACLY"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "ACLY"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "ACLY"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "ACLY"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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