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ACLY Antibody - middle region (ARP42736_P050)

100 ul
$289.00
In Stock
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Conjugation Options

ARP42736_P050-FITC Conjugated

ARP42736_P050-HRP Conjugated

ARP42736_P050-Biotin Conjugated

Tested Species Reactivity:
Human
Predicted Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Sheep, Zebrafish
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality:
Polyclonal
Host:
Rabbit
Application:
WB
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
ACLY
Official Gene Full Name:
ATP citrate lyase
NCBI Gene Id:
47
Protein Name:
ATP-citrate synthase
Swissprot Id:
P53396
Protein Accession #:
NP_001087
Nucleotide Accession #:
NM_001096
Alias Symbols:
ACL, ATPCL, CLATP
Replacement Item:
This antibody may replace item sc-30537 from Santa Cruz Biotechnology.
Description of Target:
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acety
Protein Size (# AA):
1101
Molecular Weight:
121kDa
Purification:
Affinity Purified
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express ACLY.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express ACLY.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human ACLY
Predicted Homology Based on Immunogen Sequence:
Cow: 92%; Dog: 93%; Guinea Pig: 86%; Horse: 92%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 100%; Rat: 93%; Sheep: 92%; Zebrafish: 79%
Complete computational species homology data:
Anti-ACLY (ARP42736_P050)
Peptide Sequence:
Synthetic peptide located within the following region: SRTASFSESRADEVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRHTKAI
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
UBC; UBR4; SIRT2; HUWE1; ISG15; KAT2B; SUMO2; SUMO3; STAU1; SUMO1; NEDD8; MDM2; ASB15; WWOX; TRIM25; MAGED2; BAG3; PPP6C; NCL; MCM6; MCM2; KPNA4; KPNA2; PRMT1; CDKN2A; SRRT; UBD; FN1; APP; SHC1; CUL3; CAND1; CUL2; SIRT7; UL27; HDAC5; TERF2; TERF1; GSK3B;
Blocking Peptide:
For anti-ACLY (ARP42736_P050) antibody is Catalog # AAP42736 (Previous Catalog # AAPP24960)
Datasheets/Manuals:
Printable datasheet for anti-ACLY (ARP42736_P050) antibody
Sample Type Confirmation:

ACLY is strongly supported by BioGPS gene expression data to be expressed in ACHN

Target Reference:
0
Publications:

Convertini, P; Menga, A; Andria, G; Scala, I; Santarsiero, A; Castiglione Morelli, MA; Iacobazzi, V; Infantino, V; The contribution of the citrate pathway to oxidative stress in Down syndrome. 149, 423-431 (2016). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Sheep, Zebrafish 27502741

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