ACKR1 Antibody (OACA04814)

Catalog No: OACA04814

Immunofluorescent analysis of HepG2 cells at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Western blot
All lanes: ACKR1 antibody at 2ug/ml
Lane 1: mouse kidney tissue
Lane 2mouse spleen tissue
Secondary
Goat polyclonal to rabbit at 1/1,0000 dilution
Predicted band size: 36kDa
Observed band size: 36kDa

Western blot
All lanes: ACKR1 antibody at 2ug/ml
Lane 1: mouse kidney tissue
Lane 2mouse spleen tissue
Secondary
Goat polyclonal to rabbit at 1/1,0000 dilution
Predicted band size: 36kDa
Observed band size: 36kDa

Immunofluorescent analysis of HepG2 cells at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Product Info

• Predicted Species Reactivity: Human|Mouse
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Western blot
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human Atypical chemokine receptor 1 protein (1-63AA)
• Purification: Protein G Purified
• Preservative: 0.03% Proclin 300
• Formulation: 50% Glycerol, 0.01M PBS, PH 7.4
• Reference: [1]"Admixture mapping of white cell count: genetic locus responsible for lower white blood cell count in the Health ABC and Jackson Heart Studies." Nalls M.A., Wilson J.G., Patterson N.J., Tandon A., Zmuda J.M., Huntsman S., Garcia M., Hu D., Li R., Beamer B.A., Patel K.V., Akylbekova E.L., Files J.C., Hardy C.L., Buxbaum S.G., Taylor H.A., Reich D., Harris T.B., Ziv E.Am. J. Hum. Genet. 82:81-87(2008). [2]"A novel mutation in the coding sequence of the FY*B allele of the Duffy chemokine receptor gene is associated with an altered erythrocyte phenotype." Parasol N., Reid M., Rios M., Castilho L., Harari I., Kosower N.S.Blood 92:2237-2243(1998). [3]"Molecular basis and PCR-DNA typing of the Fya/fyb blood group polymorphism." Tournamille C., Le van Kim C., Gane P., Cartron J.-P., Colin Y. Hum. Genet. 95:407-410(1995).

Target Info

• Gene Symbol: ACKR1
• Gene Full Name: atypical chemokine receptor 1 (Duffy blood group)
• Alias Symbols: atypical chemokine receptor 1;CCBP1;CD234;DARC;DARC/ACKR1;Dfy;Duffy antigen chemokine receptor;Duffy antigen/chemokine receptor;Duffy blood group antigen;Duffy blood group system protein;Duffy blood group, chemokine receptor;FY;Fy glycoprotein;glycoprotein D;GPD;GpFy;plasmodium vivax receptor;WBCQ1.
• NCBI Gene Id: 2532
• Protein Name: Atypical chemokine receptor 1
• Description of Target: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
• Uniprot ID: Q16570
• Protein Accession #: NP_001116423
• Nucleotide Accession #: NM_001122951