Catalog No: OAPB00219
Size:0.1 mg
Price: $439.00
SKU
OAPB00219
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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ACE2 Antibody (OAPB00219)

Datasheets/ManualsPrintable datasheet for OAPB00219
Product Info
Predicted Species ReactivityHuman, Mouse, Rat
Product FormatLiquid PBS with 0.02% sodium azide
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ConjugationUnconjugated
ApplicationELISA, WB, IHC-P, IF
Additional InformationPositive Control: Human Kidney, Human Spleen
Reconstitution and StorageStored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
ImmunogenAnti-ACE2 antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human ACE2.
The immunogen is located within the first 50 amino acids of ACE2.
PurificationACE2 Antibody is affinity chromatography purified via peptide column.
Predicted Homology Based on Immunogen SequencePredicted species reactivity based on immunogen sequence: Bovine: (86%)
Concentration1 mg/mL
Blocking PeptideFor anti-ACE2 antibody is Catalog # OEPB02313
SpecificityAnti-ACE2 has no cross response to ACE1.
Application InfoWB: 1-2 ug/mL
IHC: 2 ug/mL
IF: 10 ug/mL. Antibody validated: WB in human, mouse and rat samples; IHC in human samples; IF in human, mouse and rat samples.
ReferenceDonoghue et al. Circ. Res. 2000;87:1-9.
Tipnis et al. J Biol. Chem. 2000;275:33238-43.
Li et al. Nature 2003;426:450-4.
Lu et al. The Lancet 2020 (published online).
Crackower et al. Nature 2002;417:822-8.
Gene SymbolACE2
Gene Full Nameangiotensin I converting enzyme (peptidyl-dipeptidase A) 2
Alias SymbolsACEH
NCBI Gene Id59272
Protein NameAngiotensin-converting enzyme 2
Description of TargetAngiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. Homology modeling shows 2019-nCoV has a similar receptor-binding domain structure as SARS-CoV, which suggests COVID-19 (2019-nCoV) may use ACE2 as a receptor in humans for infection. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
Swissprot IdQ9BYF1
Protein Accession #NP_068576
Molecular WeightPredicted: 93kDa
Observed: 130 kDa (7 N-linked glycosylation)
Tissue ToolFind tissues and cell lines supported by DNA array analysis to express ACE2.
RNA SeqFind tissues and cell lines supported by RNA-seq analysis to express ACE2.
  1. What is the species homology for "ACE2 Antibody (OAPB00219)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat".

  2. How long will it take to receive "ACE2 Antibody (OAPB00219)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".

  3. What buffer format is "ACE2 Antibody (OAPB00219)" provided in?

    This item is provided in "Liquid PBS with 0.02% sodium azide".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "ACE2 Antibody (OAPB00219)"?

    This target may also be called "ACEH" in publications.

  5. What is the shipping cost for "ACE2 Antibody (OAPB00219)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "ACE2 Antibody (OAPB00219)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "ACE2 Antibody (OAPB00219)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "Predicted: 93kDa
    Observed: 130 kDa (7 N-linked glycosylation) ".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "ACE2 Antibody (OAPB00219)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "ACE2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "ACE2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "ACE2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "ACE2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "ACE2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "ACE2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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