Catalog No: OASG00144
Size:100 uL
Price: $239.00
SKU
OASG00144
Availability: Domestic: within 1 week delivery | International: 1 week
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ACE2 Antibody - middle region (OASG00144)

Datasheets/ManualsPrintable datasheet for anti-ACE2 (OASG00144) antibody
Product Info
Predicted Species ReactivityHuman, Mouse
Product FormatLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ConjugationUnconjugated
ApplicationWB, ELISA
Additional InformationCellular Localization: Processed angiotensin-converting enzyme 2: Secreted.; Cell membrane; Single-pass type I membrane protein. Cytoplasm. Detected in both cell membrane and cytoplasm in neurons.
Tissue Specificity: Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system.
Reconstitution and StorageStore at -20°C. Avoid repeated freeze/thaw cycles.
ImmunogenSynthesized peptide derived from the Internal region of human ACE2.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration1 mg/ml
Target Post-Translational ModificationN-glycosylation on Asn-90 may limit SARS infectivity. Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1.
SpecificityACE2 Polyclonal Antibody detects endogenous levels of ACE2 protein.
Application InfoWB: 1:500-1:2000
ELISA: 1:40,000
Optimal dilutions should be determined by the end user.
Publications

Activation of Kinin B1R Upregulates ADAM17 and Results in ACE2 Shedding in Neurons. Int J Mol Sci. 22, (2020). 33375653

Expression of ACE2 in Human Neurons Supports the Neuro-Invasive Potential of COVID-19 Virus. Cell Mol Neurobiol. NULL, NULL (2020). 32623546

Gene SymbolACE2
Gene Full Nameangiotensin I converting enzyme 2
Alias SymbolsACEH
NCBI Gene Id59272; 70008;
Description of TargetCarboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. (Microbial infection) Acts as a receptor for SARS coronavirus/SARS-CoV and human coronavirus NL63/HCoV-NL63.
Swissprot IdQ9BYF1, Q8R0I0
Molecular Weight90 kDa
Tissue ToolFind tissues and cell lines supported by DNA array analysis to express ACE2.
RNA SeqFind tissues and cell lines supported by RNA-seq analysis to express ACE2.
  1. What is the species homology for "ACE2 Antibody - middle region (OASG00144)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse".

  2. How long will it take to receive "ACE2 Antibody - middle region (OASG00144)"?

    This item is available "Domestic: within 1 week delivery | International: 1 week".

  3. What buffer format is "ACE2 Antibody - middle region (OASG00144)" provided in?

    This item is provided in "Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "ACE2 Antibody - middle region (OASG00144)"?

    This target may also be called "ACEH" in publications.

  5. What is the shipping cost for "ACE2 Antibody - middle region (OASG00144)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "ACE2 Antibody - middle region (OASG00144)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "ACE2 Antibody - middle region (OASG00144)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "90 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "ACE2 Antibody - middle region (OASG00144)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "ACE2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "ACE2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "ACE2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "ACE2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "ACE2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "ACE2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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