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Catalog No: OAAB05862
Size:400ul
Price: $438.00
SKU
OAAB05862
Availability: Domestic: within 1-2 week delivery | International: within 1-2 week delivery
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Datasheets/ManualsPrintable datasheet for anti-ACCN2 antibody - OAAB05862
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid. PBS with 0.09% (W/V) sodium azide.
ClonalityPolyclonal
IsotypeIg
HostRabbit
ApplicationFC, IHC-P, WB
Additional InformationFunction: Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.
Cellular Location Cell membrane; Multi- pass membrane protein Note=Localizes in synaptosomes at dendritic synapses of neurons Colocalizes with DLG4 (By similarity).
Tissue Location Expressed in most or all neurons.
Reconstitution and StorageMaintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThis ACCN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 500-526 amino acids from the C-terminal region of human ACCN2.
PurificationThis antibody is purified through a protein A column, followed by peptide affinity purification.
Predicted Homology Based on Immunogen SequenceChicken, Mouse, Rat
ConcentrationApproximately 0.5mg/ml. Actual concentration varies with each lot.
Intended UseACCN2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Application InfoWB: 1:1000
IHC-P: 1:50~100
FC: 1:10~50
Other Applications Image 1 DataACCN2 Antibody (C-term) flow cytometric analysis of CEM cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Gene SymbolACCN2
Alias SymbolsASIC, ACCN2, BNaC2
NCBI Gene Id41
Protein NameAcid-sensing ion channel 1
Description of TargetACCN2 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown.
Uniprot IDP78348
Protein Accession #NP_001086.2
Molecular Weight60 kDa
  1. What is the species homology for "ACCN2 Antibody - C-terminal region (OAAB05862)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "ACCN2 Antibody - C-terminal region (OAAB05862)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "ACCN2 Antibody - C-terminal region (OAAB05862)" provided in?

    This item is provided in "Liquid. PBS with 0.09% (W/V) sodium azide.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "ACCN2 Antibody - C-terminal region (OAAB05862)"?

    This target may also be called "ASIC, ACCN2, BNaC2" in publications.

  5. What is the shipping cost for "ACCN2 Antibody - C-terminal region (OAAB05862)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "ACCN2 Antibody - C-terminal region (OAAB05862)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "ACCN2 Antibody - C-terminal region (OAAB05862)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "60 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "ACCN2 Antibody - C-terminal region (OAAB05862)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "ACCN2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "ACCN2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "ACCN2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "ACCN2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "ACCN2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "ACCN2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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