ACACA Antibody (Phospho-Ser79) (OAAN02936)

Catalog No: OAAN02936

Western blot analysis of extracts from 293 cells using Phospho-ACACA-S79 antibody.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. PBS with 0.02% sodium azide, 50% glycerol, pH 7.3
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: WB
• Reconstitution and Storage: Store at -20°C. Avoid repeated freeze/thaw cycles.
• Immunogen: A phospho-Serpecific peptide corresponding-Thro residues-Serurrounding-Ser79 of human ACACA
• Purification: Affinity purification.
• Target Post-Translational Modification: Phospho-Ser79
• Intended Use: For research purposes only. Not for therapeutic or diagnostic purposes in humans or animals.
• Application Info: WB: 1:500~2000
  
• Publications:

  Adult-onset obesity is triggered by impaired mitochondrial gene expression. Sci Adv. 3, e1700677 (2017). 28835921

  Reduced mitochondrial translation prevents diet-induced metabolic dysfunction but not inflammation. Aging (Albany NY). 12, 19677-19700 (2020). 33024056

Target Info

• Gene Symbol: ACACA
• Gene Full Name: acetyl-CoA carboxylase alpha
• Alias Symbols: ACC, ACAC, ACC1, ACCA, ACACAD
• NCBI Gene Id: 31
• Protein Name: Acetyl-CoA carboxylase 1
• Description of Target: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
• Uniprot ID: Q13085
• Protein Accession #: NP_942131.1
• Nucleotide Accession #: NM_198834.2
• Molecular Weight: 265 kDa