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Catalog No: OAAB17212
Price: $438.00
Availability: Domestic: within 1-2 week delivery | International: within 1-2 week delivery
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Datasheets/ManualsPrintable datasheet for OAAB17212
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityMouse, Zebrafish
Product FormatLiquid. PBS with 0.09% (W/V) sodium azide
Additional InformationFunction: Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired Phosphorylates TP73, a primary regulator for this type of damage- induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin- associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21- dependent manner. Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity.
::Cellular Location: Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Note=Shuttles between the nucleus and cytoplasm depending on environmental signals. Sequestered into the cytoplasm through interaction with 14-3-3 proteins. Localizes to mitochondria in response to oxidative stress.
Tissue Location: Widely expressed.
Reconstitution and StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThis ABL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-260 amino acids from the N-terminal region of human ABL1.
PurificationThis antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration0.28 mg/ml
Intended UseFor research use only and not for use in diagnostic or therapeutic procedures.
Application InfoWB: 1:1,000
Optimal dilutions should be determined by the end user.
ReferenceDonaldson, L.W., et al., Proc. Natl. Acad. Sci. U.S.A. 99(22):14053-14058 (2002).
Pisabarro, M.T., et al., J. Mol. Biol. 281(3):513-521 (1998).
Nam, H.J., et al., Structure 4(9):1105-1114 (1996).
Chissoe, S.L., et al., Genomics 27(1):67-82 (1995).
Gosser, Y.Q., et al., Structure 3(10):1075-1086 (1995).
Gene SymbolABL1
Alias SymbolsABL, JTK7, p150, c-ABL, v-abl, CHDSKM, c-ABL1, BCR-ABL, bcr/abl
NCBI Gene Id25
Protein NameTyrosine-protein kinase ABL1
Description of TargetThe ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.
Uniprot IDP00519
Protein Accession #NP_005148.2
Molecular Weight123 kDa
  1. What is the species homology for "ABL1 Antibody - N-terminal region (OAAB17212)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Mouse, Zebrafish".

  2. How long will it take to receive "ABL1 Antibody - N-terminal region (OAAB17212)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "ABL1 Antibody - N-terminal region (OAAB17212)" provided in?

    This item is provided in "Liquid. PBS with 0.09% (W/V) sodium azide".
    Additional format options may be available. For more information please contact

  4. What are other names for "ABL1 Antibody - N-terminal region (OAAB17212)"?

    This target may also be called "ABL, JTK7, p150, c-ABL, v-abl, CHDSKM, c-ABL1, BCR-ABL, bcr/abl" in publications.

  5. What is the shipping cost for "ABL1 Antibody - N-terminal region (OAAB17212)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "ABL1 Antibody - N-terminal region (OAAB17212)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "ABL1 Antibody - N-terminal region (OAAB17212)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "123 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "ABL1 Antibody - N-terminal region (OAAB17212)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "ABL1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "ABL1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "ABL1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "ABL1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "ABL1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "ABL1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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