ABHD2 Antibody - middle region (OAAB09376)

Catalog No: OAAB09376

Size:400ul

ABHD2 Antibody (Center) (Cat. #OAAB09376) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the ABHD2 antibody detected the ABHD2 protein (arrow).

ABHD2 Antibody (Center) (Cat. #OAAB09376)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ABHD2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

Product Info

• Predicted Species Reactivity: Human, Mouse, Cow, Monkey
• Product Format: Liquid. PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Host: Rabbit
• Application: WB, IHC-P
  Function: Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1AG and 2AG to glycerol and arachidonic acid (AA). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation. May also play a role in smooth muscle cells migration (By similarity).
  Cellular Location: Cell projection, cilium, flagellum membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein.
  Tissue Location: Present in sperm (at protein level).
  
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This ABHD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the Central region of human ABHD2.
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Predicted Homology Based on Immunogen Sequence: Cow; Human; Mouse; Monkey
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Intended Use: For research use only, not for use in diagnostic or therapeutic procedures.
• Application Info: WB: 1:1000
  IHC-P: 1:10~50

Target Info

• Gene Symbol: ABHD2
• Alias Symbols: HS1-2, LABH2, PHPS1-2
• NCBI Gene Id: 11057
• Protein Name: Abhydrolase domain-containing protein 2
• Description of Target: This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. The function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants encoding the same protein [provided by RefSeq].
• Uniprot ID: P08910
• Protein Accession #: NP_008942.3
• Molecular Weight: 48315 Da