ABCG2 Recombinant Protein (OPCD01015)

Catalog No: OPCD01015

ABCG2 Recombinant Protein (OPCD01015) using SDS-PAGE

ABCG2 Recombinant Protein (OPCD01015) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Met1-Pro290
  Predicted isoelectric point: 8.8
  Subcellular Location: Membrane
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/ml (prior to lyoph)
• Purity: > 97%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: ABCG2
• Gene Full Name: ATP binding cassette subfamily G member 2 (Junior blood group)
• Alias Symbols: ABC transporter;ABC15;ABCP;ATP-binding cassette transporter G2;ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group);BCRP;BCRP1;BMDP;breast cancer resistance protein;broad substrate specificity ATP-binding cassette transporter ABCG2;CD338;CDw338;EST157481;GOUT1;mitoxantrone resistance-associated protein;MRX;multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2;MXR;MXR1;MXR-1;placenta specific MDR protein;placenta-specific ATP-binding cassette transporter;UAQTL1;urate exporter.
• NCBI Gene Id: 9429
• Protein Name: ATP-binding cassette sub-family G member 2
• Description of Target: High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.
• Uniprot ID: Q9UNQ0
• Protein Accession #: NP_001244315.1
• Nucleotide Accession #: NM_001257386.1
• Protein Size (# AA): Met1~Pro290
• Molecular Weight: 35kDa