ABCD1 Antibody - middle region (OAAB00467)

Catalog No: OAAB00467

Size:400ul

ABCD1 Antibody (Center) western blot analysis in HL-60 cell lysates (35ug/lane).This demonstrates the ABCD1 antibody detected the ABCD1 protein (arrow).

ABCD1 is supported by BioGPS gene expression data to be expressed in HL60

ABCD1 antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ABCD1 antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Mouse, Rat
• Product Format: Liquid PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Host: Rabbit
• Application: WB, IHC-P, FC
• Additional Information: Cellular Location: Peroxisome membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein Lysosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Reconstitution and Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This ABCD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-285 amino acids from the Central region of human ABCD1.
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: 0.5 mg/ml
• Sample Type Confirmation:

  ABCD1 is supported by BioGPS gene expression data to be expressed in HL60

• Application Info: WB: 1:1000
  IHC-P: 1:50~100
  FC: 1:10~50

Target Info

• Gene Symbol: ABCD1
• Alias Symbols: ALD, AMN, ALDP, ABC42
• NCBI Gene Id: 215
• Protein Name: ATP-binding cassette sub-family D member 1
• Description of Target: ABCD1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system.
• Uniprot ID: P33897
• Protein Accession #: NP_000024.2
• Molecular Weight: 83 kDa