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ABCD1 Antibody - middle region (OAAB00467)

400ul
$390.00
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Gene Symbol:
ABCD1
NCBI Gene Id:
215
Protein Name:
ATP-binding cassette sub-family D member 1
Swissprot Id:
P33897
Protein Accession #:
NP_000024.2
Alias Symbols:
ABCD1,ATP-binding cassette sub-family D member 1,ALD
Replacement Item:
This antibody may replace item sc-171621 from Santa Cruz Biotechnology.
Description of Target:
ABCD1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system.
Molecular Weight:
83 kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Application:
WB, IHC-P, FC, ELISA
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express ABCD1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express ABCD1.
Immunogen:
This ABCD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-285 amino acids from the Central region of human ABCD1.
Predicted Species Reactivity:
Mouse, Rat
Tested Species Reactivity:
Human
Product Format:
Liquid PBS with 0.09% (W/V) sodium azide.
Reconstitution and Storage:
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Concentration:
0.5 mg/ml
Datasheets/Manuals:
Printable datasheet for anti-ABCD1 antibody - OAAB00467
Sample Type Confirmation:

ABCD1 is supported by BioGPS gene expression data to be expressed in HL60

Isotype:
Rabbit Ig
Application Info:
WB: 1:1000
IHC-P: 1:50~100
FC: 1:10~50
Additional Information:
Cellular Location: Peroxisome membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein Lysosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

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