Size:100 ul
$319.00
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ARP43622_P050-FITC
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Conjugation Options

ARP43622_P050 Unconjugated

ARP43622_P050-HRP Conjugated

ARP43622_P050-Biotin Conjugated

ABCC8 Antibody - N-terminal region : FITC (ARP43622_P050-FITC)

Catalog#: ARP43622_P050-FITC
Domestic: within 1-2 days delivery | International: 1-2 days
More Information
Predicted Species Reactivity Cow, Dog, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
Product Format Liquid. Purified antibody supplied in 1x PBS buffer.
Clonality Polyclonal
Host Rabbit
Conjugation FITC (FAM): Excitation 495 nm/ Emission 520 nm
Application IHC, WB
Additional Information IHC Information: Paraffin embedded small intestine tissue, tested with an antibody dilution of 5 ug/ml.
Reconstitution and Storage All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Replacement Item This antibody may replace item sc-25683 from Santa Cruz Biotechnology.
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human ABCC8
Purification Affinity Purified
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 85%
Complete computational species homology data Anti-ABCC8 (ARP43622_P050)
Peptide Sequence Synthetic peptide located within the following region: PLAFCGSENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIGW
Concentration 0.5 mg/ml
Blocking Peptide For anti-ABCC8 (ARP43622_P050-FITC) antibody is Catalog # AAP43622 (Previous Catalog # AAPS15903)
Datasheets/Manuals Printable datasheet for anti-ABCC8 (ARP43622_P050-FITC) antibody
Target Reference Chiannilkulchai,N., (2008) J. Biol. Chem. 283 (14), 8778-8782
Gene Symbol ABCC8
Official Gene Full Name ATP-binding cassette, sub-family C (CFTR/MRP), member 8
Alias Symbols ABC36, HHF1, HI, HRINS, MRP8, PHHI, SUR, SUR1, TNDM2, SUR1delta2
NCBI Gene Id 6833
Protein Name ATP-binding cassette sub-family C member 8
Description of Target ABCC8 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCC8 is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion.The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Swissprot Id Q09428
Protein Accession # NP_000343
Nucleotide Accession # NM_000352
Protein Size (# AA) 1581
Molecular Weight 177kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express ABCC8.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express ABCC8.
Protein Interactions ENSA; KCNJ11; CRYBB1; KCNJ8; RAPGEF4;
  1. What is the species homology for "ABCC8 Antibody - N-terminal region : FITC (ARP43622_P050-FITC)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Cow, Dog, Human, Mouse, Pig, Rabbit, Rat, Zebrafish".

  2. How long will it take to receive "ABCC8 Antibody - N-terminal region : FITC (ARP43622_P050-FITC)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "ABCC8 Antibody - N-terminal region : FITC (ARP43622_P050-FITC)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "ABCC8 Antibody - N-terminal region : FITC (ARP43622_P050-FITC)"?

    This target may also be called "ABC36, HHF1, HI, HRINS, MRP8, PHHI, SUR, SUR1, TNDM2, SUR1delta2" in publications.

  5. What is the shipping cost for "ABCC8 Antibody - N-terminal region : FITC (ARP43622_P050-FITC)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "ABCC8 Antibody - N-terminal region : FITC (ARP43622_P050-FITC)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "ABCC8 Antibody - N-terminal region : FITC (ARP43622_P050-FITC)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "177kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "ABCC8 Antibody - N-terminal region : FITC (ARP43622_P050-FITC)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "ABCC8"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "ABCC8"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "ABCC8"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "ABCC8"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "ABCC8"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "ABCC8"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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