ABCB4 Antibody - Biotin Conjugated (OACA00085)

Catalog No: OACA00085

Size:100ug

Product Info

• Predicted Species Reactivity: Mouse
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Biotin
• Application: Enzyme-linked immunosorbent assay
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Mouse Phosphatidylcholine translocator ABCB4 protein (352-708AA)
• Purification: Protein G Purified
• Purity: Caprylic Acid Ammonium Sulfate Precipitation purified
• Reference: [1] Cloning and characterization of a second member of the mouse mdr gene family.'Gros P., Raymond M., Bell J., Housman D.Mol. Cell. Biol. 8:2770-2778(1988)
  [2] Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.Submitted (JUL-2005)
  [3] The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).'The MGC Project Team Genome Res. 14:2121-2127(2004)
• Storage Buffer: Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Target Info

• Gene Symbol: Abcb4
• Gene Full Name: ATP-binding cassette, sub-family B (MDR/TAP), member 4
• Alias Symbols: ATP-binding cassette sub-family B member 4;Mdr;mdr-;mdr-2;Mdr2;multidrug resistance protein 2;multidrug resistance protein 3;P glycoprotein 2;P-glycoprotein 2;P-glycoprotein 3;Pgy;Pgy-;Pgy2;Pgy-2;phosphatidylcholine translocator ABCB4.
• NCBI Gene Id: 18670
• Protein Name: Phosphatidylcholine translocator ABCB4
• Description of Target: Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi between hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:8106172, PubMed:7912658, PubMed:7592705, PubMed:7814632, PubMed:8725158, PubMed:9366571). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes (By similarity). Required for proper phospholipid bile formation (PubMed:8106172). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:7814632, PubMed:8725158). May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (PubMed:1990275).
• Uniprot ID: P21440
• Protein Accession #: NP_000434.1; NP_061337.1; NP_061338.1
• Nucleotide Accession #: NM_000443.3; NM_018849.2; NM_018850.2