ABCB1 Antibody - middle region (OABB00919)

Catalog No: OABB00919

Size:100UG

Anti-P Glycoprotein Picoband antibody
IHC(F): Mouse Intestine Tissue

Anti-P Glycoprotein Picoband antibody
IHC(F): Rat Kidney Tissue

Anti-P Glycoprotein Picoband antibody
IHC(P): Human Lung Cancer Tissue

Anti-P Glycoprotein Picoband antibody
IHC(P): Mouse Kidney Tissue

Anti-P Glycoprotein Picoband antibody
IHC(P): Rat Kidney Tissue

Product Info

• Tested Species Reactivity: Human, Mouse, Rat
• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Clonality: Polyclonal
• Clone: Polyclonal
• Isotype: Rabbit IgG
• Host: Rabbit
• Application: Immunohistochemistry
• Additional Information: Notes: Tested Species: In-house tested species with positive results.
  By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections.
  Other applications have not been tested.
  Optimal dilutions should be determined by end users.
  
  Background: P-GP, also called ABCB1 or PGY1, is a glycoprotein that in humans is encoded by the ABCB1 gene. It is mapped to 7q21.12. P-GP is a well-characterized ABC-transporter (which transports a wide variety of substrates across extra- and intracellular membranes) of the MDR/TAP subfamily. It is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent drug efflux pump with broad substrate specificity. P-GP is an ATP-dependent drug efflux pump forxenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood–brain barrier.
• Reconstitution and Storage: 2°C to 8°C|-20°C
• Immunogen: Polypeptide
• Purification: Affinity Purified
• Concentration: 500 ug/ml
• Specificity: No cross reactivity with other proteins.
• Application Info: Immunohistochemistry (Paraffin-embedded Section): 0.5-1 ug/ml: Human, Mouse, Rat: By Heat
  Immunohistochemistry (Frozen Section): 0.5-1 ug/ml: Mouse, Rat
• Storage Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Description: Rabbit IgG polyclonal antibody for Multidrug resistance protein 1(ABCB1) detection. Tested with IHC-P, IHC-F in Human;Mouse;Rat.

Target Info

• Gene Symbol: ABCB1
• Gene Full Name: ATP binding cassette subfamily B member 1
• Alias Symbols: ABC20;ATP-binding cassette sub-family B member 1;ATP-binding cassette, sub-family B (MDR/TAP), member 1;ATP-dependent translocase ABCB1;CD243;CLCS;colchicin sensitivity;doxorubicin resistance;GP170;MDR1;multidrug resistance protein 1;p-170;P-glycoprotein 1;P-GP;PGY1;phospholipid transporter ABCB1.
• NCBI Gene Id: 5243
• Protein Name: Multidrug resistance protein 1
• Description of Target: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
• Uniprot ID: P08183
• Molecular Weight: 141479 MW