ABCA7 Antibody - N-terminal (OAPB01594)

Catalog No: OAPB01594

Size:100 ug

Western blot analysis of ABCA7 in 293 cell lysate with ABCA7 antibody at (A) 1 and (B) 2 ug/mL.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. PBS with 0.02% sodium azide
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, ICC, IF, IHC
  Positive Control: 1) HEK293 Cell Lysate 2) Human Spleen Tissue
• Reconstitution and Storage: ABCA7 antibody can be stored at 4C for three months and -20C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Immunogen: ABCA7 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human ABCA7. The immunogen is located within amino acids 130-180 of ABCA7.
• Purification: Affinity chromatography purified via peptide column.
• Concentration: 1 mg/mL
• Specificity: ABCA7 antibody is predicted to not cross-react with other ABC1 subfamily proteins.
• Intended Use: For research use only.
• Application Info: WB: 1-2 ug/mL
  ICC: 5 ug/mL
  IHC: 5 ug/mL
  IF: 5 ug/mL
  Optimal dilutions for each application to be determined by the researcher.

Target Info

• Gene Symbol: ABCA7
• Gene Full Name: ATP binding cassette subfamily A member 7
• Alias Symbols: AD9, ABCX, ABCA-SSN
• NCBI Gene Id: 10347
• Protein Name: ATP-binding cassette sub-family A member 7
• Description of Target: ATP-binding cassette (ABC) transporters are an evolutionarily conserved family that use ATP hydrolysis to catalyze the transport of various molecules across cell membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCA7, a member of the ABC1 subfamily, is a full-size ABC transporter consisting of two sets of the multiple membrane-spanning domains plus the Walker motifs for the ATP interaction. ABCA7 shows the highest homology to ABCA1, an essential molecule for cholesterol homeostasis. The high expression levels of ABCA7 in peripheral leukocytes, thymus, spleen and bone marrow suggests a role in the immune system lipid homeostasis.
• Uniprot ID: Q8IZY2
• Protein Accession #: NP_061985
• Nucleotide Accession #: NM_019112.3
• Molecular Weight: 236 kDa