ABCA4 Recombinant Protein (OPCD01006)

Catalog No: OPCD01006

ABCA4 Recombinant Protein (OPCD01006) using SDS-PAGE

ABCA4 Recombinant Protein (OPCD01006) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Gly1398-Asn1727
  Isoelectric Point: 7.7
  Subcellular Location: Membrane.
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 150 ug/mL (prior to lyoph)
• Purity: >90%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: ABCA4
• Gene Full Name: ATP binding cassette subfamily A member 4
• Alias Symbols: ABC10;ABCR;ARMD2;ATP binding cassette transporter;ATP-binding cassette sub-family A member 4;ATP-binding cassette transporter, retinal-specific;ATP-binding cassette, sub-family A (ABC1), member 4;ATP-binding transporter, retina-specific;CORD3;FFM;photoreceptor rim protein;retinal-specific ATP-binding cassette transporter;retinal-specific phospholipid-transporting ATPase ABCA4;retina-specific ABC transporter;RIM ABC transporter;RIM protein;RMP;RP19;stargardt disease protein;STGD;STGD1.
• NCBI Gene Id: 24
• Protein Name: Retinal-specific ATP-binding cassette transporter
• Description of Target: In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.
• Uniprot ID: P78363
• Protein Accession #: NP_000341.2
• Nucleotide Accession #: NM_000350.2
• Protein Size (# AA): Gly1398~Asn1727
• Molecular Weight: 41kDa