AATF Recombinant Protein (OPCD00997)

Catalog No: OPCD00997

AATF Recombinant Protein (OPCD00997) using SDS-PAGE

AATF Recombinant Protein (OPCD00997) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ser240-Ile438
  Subcellular Location: Nucleus, nucleolus
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His and GST Tag

Target Info

• Gene Symbol: Aatf
• Gene Full Name: apoptosis antagonizing transcription factor
• Alias Symbols: 4933415H02Rik;5830465M17Rik;Apoptosis-antagonizing transcription factor;Che-1;protein AATF;rb-binding protein Che-1;Tr;traube protein;Trb.
• NCBI Gene Id: 56321
• Protein Name: Protein AATF
• Description of Target: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity).
• Uniprot ID: Q9JKX4
• Protein Accession #: NP_062790.1
• Nucleotide Accession #: NM_019816.1
• Protein Size (# AA): Ser240~Ile438
• Molecular Weight: 53kDa