AATF Recombinant Protein (OPCD00996)

Catalog No: OPCD00996

AATF Recombinant Protein (OPCD00996) using SDS-PAGE

AATF Recombinant Protein (OPCD00996) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Rat|Rattus norvegicus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ser237-Gln523
  Subcellular Location: Nucleus
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Aatf
• Gene Full Name: apoptosis antagonizing transcription factor
• Alias Symbols: Apoptosis-antagonizing transcription factor;Ded;protein AATF.
• NCBI Gene Id: 114512
• Protein Name: Protein AATF
• Description of Target: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. May negatively regulate the pro-apoptotic activity of DAPK3/ZIPK. Can act cooperatively with TSG101 to stimulate AR mediated transcription activation (By similarity). May negatively regulate the pro-apoptotic activity of DAPK3/ZIPK. Can act cooperatively with TSG101 to stimulate AR mediated transcription activation.
• Uniprot ID: Q9QYW0
• Protein Accession #: NP_446172.1
• Nucleotide Accession #: NM_053720.1
• Protein Size (# AA): Ser237~Gln523
• Molecular Weight: 44kDa