A2ML1 Recombinant Protein (OPCD00985)

Catalog No: OPCD00985

A2ML1 Recombinant Protein (OPCD00985) using SDS-PAGE

A2ML1 Recombinant Protein (OPCD00985) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Gln1119-Thr1348
  Subcellular Location: Secreted.
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: A2ML1
• Gene Full Name: alpha-2-macroglobulin like 1
• Alias Symbols: alpha-2-macroglobulin-like protein 1;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9;C3 and PZP-like, alpha-2-macroglobulin domain containing 9;CPAMD9;OMS;p170.
• NCBI Gene Id: 144568
• Protein Name: Alpha-2-macroglobulin-like protein 1
• Description of Target: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.
• Uniprot ID: A8K2U0
• Protein Accession #: NP_001269353.1
• Nucleotide Accession #: NM_001282424.2
• Protein Size (# AA): Gln1119~Thr1348
• Molecular Weight: 29kDa