- NCBI Gene Id:
- Official Gene Full Name:
- 5-hydroxytryptamine receptor 2B
- Alias Symbols:
- 5-HT2B, 5-HT(2B)
- Description of Target:
- 5HT2B Receptor is known as HTR2B. This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved.
- Immunogen affinity purified.
- Tissue Tool:
- Find tissues and cell lines supported by DNA array analysis to express 5HT2B RECEPTOR.
- RNA Seq:
- Find tissues and cell lines supported by RNA-seq analysis to express 5HT2B RECEPTOR.
- A synthetic peptide corresponding to a sequence at the C-terminus of human 5HT2B Receptor (446-478aa MRLRSSTIQSSSIILLDTLLLTENEGDKTEEQ V), different from the related mouse sequence by six amino acids, and from the related rat sequence by nine amino acids.
- Species Reactivity:
- Human, Rat
- Product Format:
- Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
- Reconstitution and Storage:
- Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml. +4C
- Application Info:
- Tested Species: In-house tested species with positive results.
Other applications have not been tested.
Optimal dilutions should be determined by end users.
- Target Reference:
- 1. "Entrez Gene: HTR2B 5-hydroxytryptamine (serotonin) receptor 2B".
2. Doly S, Valjent E, Setola V, Callebert J, Hervé D, Launay JM, Maroteaux L (Mar 2008). "Serotonin 5-HT2B receptors are required for 3,4-methylenedioxymethamphetamine-induced hyperlocomotion and 5-HT release in vivo and in vitro". The Journal of Neuroscience28 (11): 2933–40.
3. Schmuck K, Ullmer C, Engels P, Lübbert H (Mar 1994). "Cloning and functional characterization of the human 5-HT2B serotonin receptor". FEBS Letters 342 (1): 85–90.