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5HT2B RECEPTOR Antibody - C-terminal region (OABB02083)

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100 ug
$320.00
In Stock
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Gene Symbol:
5HT2B RECEPTOR
NCBI Gene Id:
3357
Official Gene Full Name:
5-hydroxytryptamine receptor 2B
Swissprot Id:
P41595
Alias Symbols:
5-HT2B, 5-HT(2B)
Description of Target:
5HT2B Receptor is known as HTR2B. This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved.
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Immunogen affinity purified.
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express 5HT2B RECEPTOR.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express 5HT2B RECEPTOR.
Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human 5HT2B Receptor (446-478aa MRLRSSTIQSSSIILLDTLLLTENEGDKTEEQ V), different from the related mouse sequence by six amino acids, and from the related rat sequence by nine amino acids.
Species Reactivity:
Human, Rat
Peptide Sequence:
Synthetic peptide located within the following region: MRLRSSTIQSSSIILLDTLLLTENEGDKTEEQ V
Product Format:
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Reconstitution and Storage:
Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml. +4C
Datasheets/Manuals:
Printable datasheet for anti-5HT2B RECEPTOR (OABB02083) antibody
Isotype:
IgG
Application Info:
Tested Species: In-house tested species with positive results.
Other applications have not been tested.
Optimal dilutions should be determined by end users.
Target Reference:
1. "Entrez Gene: HTR2B 5-hydroxytryptamine (serotonin) receptor 2B".
2. Doly S, Valjent E, Setola V, Callebert J, Hervé D, Launay JM, Maroteaux L (Mar 2008). "Serotonin 5-HT2B receptors are required for 3,4-methylenedioxymethamphetamine-induced hyperlocomotion and 5-HT release in vivo and in vitro". The Journal of Neuroscience28 (11): 2933–40.
3. Schmuck K, Ullmer C, Engels P, Lübbert H (Mar 1994). "Cloning and functional characterization of the human 5-HT2B serotonin receptor". FEBS Letters 342 (1): 85–90.
Protocol:
Tips Information:

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