4 1BBR Protein (OPPA00722)

Catalog No: OPPA00722 (Formerly GWB-8FB4F4)

Size:5UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: Lyophilized from a concentrated (1mg/ml) solution in water containing no additives. Physical appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
• Host: E. Coli
• Additional Information: Solubility: It is recommended to reconstitute the lyophilized 4-1BB Receptor in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
  Biological Activity: The activity was determined by the inhibition of 4-1BB ligand mediated stimulation of IL-8 production by human PBMC. Results: 90% inhibition using 1 ug for both 4-1BB ligand and 4-1BB receptor.
  Product Introduction: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
  Product Description: 4-1BB Soluble Receptor Recombinant Human also called Tumor necrosis factor receptor superfamily member 9 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 167 amino acids, having a molecular mass of 17718 Dalton and containing the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor. The 4-1BB Receptor is purified by proprietary chromatographic techniques.
• Reconstitution and Storage: Lyophilized 4-1BB Receptor although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution 4-1BBR should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Please prevent freeze-thaw cycles.
• Purity: Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Peptide Sequence: The sequence of the first five N - terminal amino acids was determined and was found to be Met - Glu - Arg - Thr - Arg.

Target Info

• Gene Symbol: 4 1BBR
• Alias Symbols: ILA, 4-1BB, CD137, CDw137
• NCBI Gene Id: 3604
• Protein Name: Tumor necrosis factor receptor superfamily member 9
• Description of Target: Recombinant Human 4-1BB Receptor
• Uniprot ID: Q07011
• Protein Accession #: NP_001552.2
• Protein Size (# AA): Recombinant