Catalog No: OPPA01890 (Formerly GWB-ED2B55)
Size:5UG
Price: $75.00
SKU
OPPA01890
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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Shipping Info:
- $55: Antibody & Protein in US
- $55 + $25/Kit in US
- Contact us for international orders.
Datasheets/Manuals | Printable datasheet for OPPA01890 |
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Predicted Species Reactivity | Human |
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Product Format | Recombinant 4-1BBL contains 20mM Tris buffer pH-8, 100mM NaCl and 20% glycerol. Physical appearance: Sterile Filtered colorless solution. |
Host | E. Coli |
:: | Product Introduction: 4-1BBL is a transmembrane cytokine that is part of the tumor necrosis factor (TNF) ligand family. 4-1BBL is a bidirectional signal transducer that performs as a ligand for TNFRSF9, which is a costimulatory receptor molecule in T lymphocytes. TNFSF9 and its TNFRSF9 take part in the antigen presentation development and in the generation of cytotoxic T cells. 4-1BBR is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. TNFSF9 reactivates anergic T lymphocytes as well as promoting T lymphocyte proliferation. 4-1BB Ligand is needed for the optimal CD8 responses in CD8 T cells. 4-1BBL is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. 4-1BBL is expressed by activated B cells, macrophages, dendritic cells, activated T cells, neurons and astrocytes. The interaction of 4-1BB with TNFRSF9 strongly regulates immunity and has been proposed to preferentially control T cell responses based on studies in various murin Product Description: TNFSF9 Human Recombinant fused to 37 amino acids His tag at N-terminus produced in E.Coli is a single, non-glycosylated polypeptide chain containing 222 amino acids (71-254 a.a.) and having a molecular mass of 23.8 kDa. The TNFSF9 His tag fusion protein is purified by proprietary chromatographic techniques. |
Reconstitution and Storage | 4-1BBL although stable at 10C for 3 weeks, should be stored desiccated below -18C. Please prevent freeze-thaw cycles. |
Purity | Greater than 95.0% as determined by SDS-PAGE |
Peptide Sequence | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMRE GPELSPDDPA GLLDLRQGMF AQLVAQNVLL IDGPLSWYSD PGLAGVSLTGGLSYKEDTKE LVVAKAGVYY VFFQLELRRV VAGEGSGSVS LALHLQPLRS AAGAAALALT VDLPPASSEA RNSAFGFQGR LLHLSAGQRL GVHLHTEARA RHAWQLTQGA TVLGLFRVTP EIPAGLPSPR SE. |
Gene Symbol | 4 1BBL |
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Alias Symbols | CD137L, TNLG5A, 4-1BB-L |
NCBI Gene Id | 8744 |
Protein Name | Tumor necrosis factor ligand superfamily member 9 |
Description of Target | Recombinant Human 4-1BB Ligand |
Uniprot ID | P41273 |
Protein Accession # | NP_003802.1 |
Protein Size (# AA) | Recombinant |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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