Biological Pathway Trends from Aviva Systems Biology

Biological pathways involve mechanisms associated with cellular changes.  Pathway cascades can lead to cellular production of new molecules, gene expression, cellular metabolism, cell death, cell motility, and a variety of cell signalling activities.

Aviva Systems Biology reviews pathway research to review research trends, and produce more relevant reagents. The table below lists popular pathways along with the percentage of publications occurring within the last year.  Each pathway is linked to reagents provided by Aviva.

RNA interference 11.0%
stem cell proliferation 10.1%
gene silencing 12.1%
innate immune response 13.0%
segmentation 10.1%
inflammatory cell apoptosis 10.3%
neurogenesis 12.3%
neuroprotection 11.2%
mesenchymal cell development 10.2%
protein ubiquitination 13.2%
autophagy 22.5%
histone acetylation 10.7%
mesenchymal cell proliferation 14.2%
histone methylation 14.1%
stem cell maintenance 13.0%
adaptive immune response 14.1%
chromatin remodeling 11.6%
chromatin silencing 10.8%
histone modification 13.2%
microglial cell activation 10.8%
chromatin modification 11.4%
triglyceride homeostasis 10.7%
histone lysine methylation 13.7%
DNA demethylation 11.6%
transdifferentiation 10.4%
Notch signaling pathway 14.2%
histone H3 acetylation 11.8%
cell redox homeostasis 10.4%
chromatin maintenance 12.3%
Toll signaling pathway 13.5%
chromatin assembly or disassembly 11.6%
mesenchymal cell apoptosis 15.4%
toll-like receptor signaling pathway 13.7%
endoplasmic reticulum unfolded protein response 17.0%
nucleosome assembly 10.4%
post-translational protein acetylation 11.0%
lymphangiogenesis 13.8%
protein sumoylation 13.4%
autophagic cell death 16.5%
vascular endothelial growth factor receptor signaling pathway 11.0%
BMP signaling pathway 12.0%
toll-like receptor 1 signaling pathway 13.4%
store-operated calcium entry 10.0%
sprouting angiogenesis 12.8%
Wnt receptor signaling pathway 14.6%
toll-like receptor 4 signaling pathway 13.9%
pre-miRNA processing 20.1%
toll-like receptor 2 signaling pathway 13.2%
anti-apoptosis 11.8%
catabolic process 10.7%
mitochondrial fission 15.8%
kinetochore assembly 12.6%
toll-like receptor 3 signaling pathway 13.1%
anoikis 12.8%
neural precursor cell proliferation 10.5%
cell fate commitment 11.1%
nucleosome positioning 10.5%
protein polyubiquitination 13.7%
peroxisome proliferator activated receptor signaling pathway 10.9%
androgen receptor signaling pathway 11.8%
nucleosome disassembly 13.5%
protein catabolic process 10.3%
macroautophagy 17.7%
histone ubiquitination 17.9%
myeloid cell homeostasis 13.7%
nitric oxide storage 10.8%
heterochromatin assembly 11.3%
tendon cell differentiation 10.4%
germ-line stem cell maintenance 14.4%
T-helper 17 cell differentiation 20.2%
cilium assembly 12.7%
progesterone receptor signaling pathway 11.2%
protein glutathionylation 16.6%
toll-like receptor 7 signaling pathway 13.1%
protein monoubiquitination 16.3%
protein lipidation 12.0%
chronological cell aging 11.8%
toll-like receptor 9 signaling pathway 12.8%
smoothened signaling pathway 15.8%
somatic stem cell maintenance 17.6%
virus-host interaction 11.5%
neuronal stem cell maintenance 11.7%
canonical Wnt receptor signaling pathway 17.0%
protein deubiquitination 11.6%
reactive oxygen species metabolic process 10.9%
neuroblast proliferation 12.3%
protein lipoylation 15.2%
kinetochore organization 10.3%
natural killer cell degranulation 16.3%
mitochondrial respiratory chain complex assembly 11.5%
response to endoplasmic reticulum stress 13.7%
dendritic spine morphogenesis 15.8%
primary miRNA processing 21.1%
superior temporal gyrus development 16.4%
glycerol metabolic process 11.2%
microtubule severing 11.8%
oncogene-induced senescence 22.9%
MyD88-dependent toll-like receptor signaling pathway 13.5%
stress-induced premature senescence 10.0%
extracellular matrix disassembly 11.5%
organic acid metabolic process 11.0%
cellular response to cold 10.4%
histone H2A ubiquitination 14.6%
histone H2B ubiquitination 15.3%
protein neddylation 15.9%
response to unfolded protein 14.5%
succinate metabolic process 11.3%
ribosomal small subunit biogenesis 10.9%
ephrin receptor signaling pathway 11.3%
cell-cell junction organization 11.0%
synaptic vesicle clustering 10.2%
flavonoid metabolic process 10.2%
multivesicular body sorting pathway 12.8%
axon cargo transport 10.5%
neural crest cell fate specification 12.8%
MyD88-independent toll-like receptor signaling pathway 11.0%
stress granule assembly 21.7%
protein K63-linked ubiquitination 21.0%
posterior head segmentation 11.5%
common myeloid progenitor cell proliferation 10.7%
protein autoubiquitination 13.9%
T-helper cell lineage commitment 13.4%
heme export 10.3%
oxidative DNA demethylation 15.2%
interkinetic nuclear migration 13.0%
DNA catabolic process 10.0%
oxidative stress-induced premature senescence 11.2%
histone monoubiquitination 26.7%
base-excision repair, DNA ligation 13.1%
peroxisome fission 17.1%
Golgi ribbon formation 13.4%
RNA catabolic process 12.2%
protein desumoylation 12.5%
response to misfolded protein 21.1%
epithelial to mesenchymal transition 24.3%
mesenchymal to epithelial transition 24.3%
intein-mediated protein splicing 11.0%
zinc ion transmembrane transport 11.0%
anatomical structure regression 12.5%
cellular response to misfolded protein 19.7%
protein deglutathionylation 18.3%
medium-chain fatty acid biosynthetic process 14.3%
G2/M transition DNA damage checkpoint 11.4%
protein targeting to plasma membrane 11.4%
urate metabolic process 13.0%
heme metabolic process 10.3%
telomere maintenance via telomerase 11.9%
proteasome regulatory particle assembly 22.7%
signalosome assembly 10.6%
collagen catabolic process 16.1%
embryonic pectoral fin morphogenesis 11.5%
mRNA catabolic process 13.6%
T-helper 1 cell lineage commitment 15.8%
hepatoblast differentiation 12.5%
glial cell fate commitment 10.7%
cullin deneddylation 10.9%
proepicardium development 16.7%
mitochondrial respiratory chain complex II assembly 16.7%
neuromast development 11.3%
valine metabolic process 13.5%
formate metabolic process 11.5%
Wnt receptor signaling pathway, planar cell polarity pathway 20.0%
age-dependent telomere shortening 16.0%
sinoatrial node cell differentiation 14.0%
histone deubiquitination 12.0%
double-strand break repair via nonhomologous end joining 10.0%
replication fork protection 24.5%
Roundabout signaling pathway 14.3%
vitamin K metabolic process 12.2%
butyrate metabolic process 12.2%
protein homooligomerization 10.2%
septin ring assembly 14.6%
cytosol to ER transport 10.4%
hippo signaling cascade 36.2%
membrane to membrane docking 12.8%
piRNA metabolic process 13.0%
polyphosphate metabolic process 10.9%
non-canonical Wnt receptor signaling pathway 27.3%
CD24 biosynthetic process 15.9%
mitochondrial protein catabolic process 15.9%
ATP catabolic process 11.4%
fumarate metabolic process 11.4%
central nervous system vasculogenesis 11.6%
protein K48-linked ubiquitination 14.3%
short-chain fatty acid metabolic process 22.0%
L-serine catabolic process 19.5%
cell surface pattern recognition receptor signaling pathway 10.0%
thermosensory behavior 15.4%
sister chromatid biorientation 21.1%
protein targeting to lysosome 10.5%
oxaloacetate metabolic process 10.8%
multicellular organismal development 19.4%
T-tubule organization 17.1%
protein localization to synapse 11.8%
leptin-mediated signaling pathway 12.1%
telomere maintenance via recombination 12.5%
circadian sleep/wake cycle, REM sleep 12.5%
helper T cell extravasation 12.5%
stress granule disassembly 16.7%
corticospinal tract morphogenesis 13.3%
nucleotide-excision repair, DNA gap filling 10.0%
syncytial blastoderm mitotic cell cycle 10.0%
copper ion import 10.0%
endoplasmic reticulum tubular network organization 13.8%
histone H4-K16 acetylation 13.8%
isoleucine metabolic process 17.9%
cytoplasmic mRNA processing body assembly 18.5%
histone H2A monoubiquitination 19.2%
myelination in peripheral nervous system 19.2%
low-density lipoprotein particle remodeling 11.5%
T-helper 17 cell chemotaxis 20.0%
astrocyte fate commitment 16.0%
plasma membrane to endosome transport 12.0%
dendrite self-avoidance 34.8%
retrograde axon cargo transport 17.4%
telomere maintenance via telomere shortening 13.6%
UDP-glucose metabolic process 20.0%
retrograde transport, endosome to Golgi 10.0%
transposition, DNA-mediated 10.0%
endosomal lumen acidification 21.1%
PML body organization 10.5%
cloacal septation 10.5%
glutamine catabolic process 10.5%
one-carbon metabolic process 22.2%
interleukin-6-mediated signaling pathway 22.2%
histone H3-S10 phosphorylation 22.2%
phytol metabolic process 11.1%
pyridoxal 5-phosphate salvage 11.1%
tumor necrosis factor-mediated signaling pathway 17.6%
receptor localization to synapse 11.8%
glycolate metabolic process 11.8%
cellular response to glucose starvation 12.5%
estrogen catabolic process 12.5%
lysosomal lumen acidification 26.7%
heparan sulfate proteoglycan metabolic process 13.3%
histone H4-K5 acetylation 13.3%
oligodendrocyte cell fate commitment 13.3%
lipopolysaccharide-mediated signaling pathway 28.6%
sphingolipid catabolic process 21.4%
branchiomeric skeletal muscle development 14.3%
cellular response to insulin stimulus 14.3%
aggresome assembly 14.3%
nucleotide-excision repair, DNA duplex unwinding 14.3%
ferrous iron import 30.8%
M phase specific microtubule process 15.4%
fructose catabolic process 16.7%
ruffle assembly 16.7%
lymphocyte chemotaxis across high endothelial venule 16.7%
glycosphingolipid catabolic process 16.7%
iridophore differentiation 18.2%
early endosome to late endosome transport 18.2%
multicellular organismal aging 50.0%
lysine catabolic process 40.0%
glucosamine catabolic process 30.0%
nucleotide-binding oligomerization domain containing signaling pathway 20.0%
water-soluble vitamin metabolic process 10.0%
protein folding in endoplasmic reticulum 10.0%
succinyl-CoA metabolic process 10.0%
phytoalexin metabolic process 10.0%
protein localization in mitochondrion 10.0%
nitric oxide production involved in inflammatory response 10.0%
response to UV-C 11.1%
nucleotide-excision repair, DNA incision, 3-to lesion 11.1%
ventral spinal cord interneuron fate determination 11.1%
exogenous drug catabolic process 11.1%
protein heterotetramerization 11.1%
very-low-density lipoprotein particle remodeling 11.1%
embryonic process involved in female pregnancy 11.1%
oenocyte development 11.1%
protein K11-linked ubiquitination 50.0%
protein linear polyubiquitination 37.5%
paranodal junction assembly 12.5%
alternative nuclear mRNA splicing, via spliceosome 12.5%
glycerol ether metabolic process 12.5%
low-density lipoprotein particle mediated signaling 12.5%
adiponectin-mediated signaling pathway 12.5%
eye pigment granule organization 12.5%
posterior lateral line neuromast primordium migration 12.5%
COPII vesicle coating 42.9%
nucleotide-binding oligomerization domain containing 2 signaling pathway 28.6%
intermediate filament bundle assembly 28.6%
glucose 1-phosphate metabolic process 14.3%
deoxyribonucleoside catabolic process 14.3%
branched chain family amino acid biosynthetic process 14.3%
de novo cotranslational protein folding 14.3%
inositol phosphate-mediated signaling 14.3%
immunoglobulin production in mucosal tissue 14.3%
histone mRNA metabolic process 50.0%
age-dependent response to reactive oxygen species 33.3%
defense response to nematode 33.3%
leukocyte migration involved in immune response 16.7%
polar body extrusion after meiotic divisions 16.7%
mitochondrial fragmentation involved in apoptosis 16.7%
dermatan sulfate proteoglycan metabolic process 16.7%
Wnt receptor signaling pathway, calcium modulating pathway 60.0%
plus-end-directed vesicle transport along microtubule 40.0%
embryonic olfactory bulb interneuron precursor migration 20.0%
diacylglycerol catabolic process 20.0%
cysteine biosynthetic process via cystathionine 20.0%
nucleoside triphosphate catabolic process 20.0%
semaphorin-plexin signaling pathway 20.0%
keratan sulfate metabolic process 20.0%
nucleotide-sugar metabolic process 50.0%
flavone metabolic process 50.0%
I-kappaB kinase/NF-kappaB cascade 25.0%
phosphatidylinositol-mediated signaling 25.0%
response to organic cyclic compound 25.0%
3-UTR-mediated mRNA stabilization 25.0%
barrier septum assembly 25.0%
cell-substrate junction assembly 25.0%
anthranilate metabolic process 25.0%
RNA splicing, via transesterification reactions 25.0%

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