Visfatin Antibody (OAPA00334)

Catalog No: OAPA00334 (Formerly GWB-BSP789)

Size:5UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: 1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
• Clonality: Monoclonal
• Clone: P4D5AT.
• Isotype: Mouse IgG1heavy chain and kappa light chain.
• Host: Mouse
• Application: WB
  Product Type: Mouse Anti Human Monoclonal.
  Product Introduction: Excess adiposity is the most important risk in the development of insulin resistance and type 2 diabetes mellitus (T2DM). Adipose tissue produces several proteins (adipocytokines) such as leptin, adiponectin, resistin, tumor necrosis factor-alpha, and IL-6, that modulate insulin sensitivity and appear to play an important role in the pathogenesis of insulin resistance, diabetes, dyslipidemia, inflammation, and atherosclerosis. However, the mechanisms by which fat tissue induces insulin resistance and the role of adipocytokines in the pathogenesis of T2DM have not been well established. Visfatin, also known as pre-B cell colony-enhancing factor (PBEF), is a cytokine that is highly expressed in visceral fat and was originally isolated as a secreted factor that synergizes with IL-7 and stem cell factors to promote the growth of B cell precursors. Visfatin homologs have been identified in carp, invertebrate mollusks, and bacteria, as well as in vertebrates, including humans and the mouse. It h
• Reconstitution and Storage: For periods up to 1 month store at 4C, for longer periods of time, store at -20C. Prevent freeze thaw cycles.
  Stability: 12 months at -20C. 1 month at 4C.
• Immunogen: The immunogen for anti-Visfatin antibody: anti-human Visfatin mAb, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with Recombinant human Visfatin amino acids 1-491 purified from E. coli.
• Purity: Visfatin antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
• Application Info: Visfatin antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1,000~ 2,000. Recommended starting dilution is 1:1,000.

Target Info

• Gene Symbol: Visfatin
• Alias Symbols: VF, PBEF, PBEF1, VISFATIN, 1110035O14Rik
• NCBI Gene Id: 10135
• Protein Name: Nicotinamide phosphoribosyltransferase
• Description of Target: Mouse Anti Human Visfatin
• Uniprot ID: P43490
• Protein Accession #: NP_005737.1