VHL Recombinant Protein (OPCD07915)

Catalog No: OPCD07915

VHL Recombinant Protein (OPCD07915) using SDS-PAGE

VHL Recombinant Protein (OPCD07915) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Rat|Rattus norvegicus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ala6-Gln175
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: >95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Vhl
• Gene Full Name: von Hippel-Lindau tumor suppressor
• Alias Symbols: pVHL;Vhlh;von Hippel-Lindau disease tumor suppressor;von Hippel-Lindau protein;von Hippel-Lindau syndrome homolog;von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase.
• NCBI Gene Id: 24874
• Protein Name: von Hippel-Lindau disease tumor suppressor
• Description of Target: Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2 (By similarity).
• Uniprot ID: Q64259
• Protein Accession #: NP_434688.1
• Nucleotide Accession #: NM_052801.1
• Protein Size (# AA): Ala6~Gln175
• Molecular Weight: 23kDa