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Catalog No: OAAB15535
Size:400ul
Price: $396.00
SKU
OAAB15535
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
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Datasheets/ManualsPrintable datasheet for OAAB15535
Product Info
Predicted Species ReactivityMouse
Product FormatLiquid. PBS with 0.09% (W/V) sodium azide.
ClonalityPolyclonal
IsotypeIg
HostRabbit
ApplicationWB
Additional InformationFunction: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process (By similarity)
::Cellular Location: Membrane; Multi-pass membrane protein (Potential)
Reconstitution and StorageMaintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThis VANGL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human VANGL2.
PurificationThis antibody is purified through a protein A column, followed by peptide affinity purification.
Predicted Homology Based on Immunogen SequenceMouse; Rat
ConcentrationApproximately 0.5mg/ml. Actual concentration varies with each lot.
Intended UseVANGL2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Application InfoWB: 1:1000
Publications

Heterozygous Vangl2(Looptail) mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair. Dis Model Mech. 10, 409-423 (2017). 28237967

Gene SymbolVANGL2
Alias SymbolsLPP1, LTAP, STB1, STBM, STBM1
NCBI Gene Id57216
Protein NameVang-like protein 2
Description of TargetPlanar cell polarity (PCP) is the term given to global cell polarization, such as the alignment of mammalian body hair along the anterior-posterior axis or the orientation of steriocilia bundles in the inner ear. VANGL2 is a PCP protein that is involved in the transmission of directional cues to align either individual cells within an epithelial sheet or multicellular clusters, which polarize as a group (Devenport and Fuchs, 2008 [PubMed 18849982]).
Uniprot IDQ9ULK5
Protein Accession #NP_065068.1
Molecular Weight59714 Da
  1. What is the species homology for "VANGL2 Antibody - N-terminal region (OAAB15535)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Mouse".

  2. How long will it take to receive "VANGL2 Antibody - N-terminal region (OAAB15535)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks ".

  3. What buffer format is "VANGL2 Antibody - N-terminal region (OAAB15535)" provided in?

    This item is provided in "Liquid. PBS with 0.09% (W/V) sodium azide.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "VANGL2 Antibody - N-terminal region (OAAB15535)"?

    This target may also be called "LPP1, LTAP, STB1, STBM, STBM1" in publications.

  5. What is the shipping cost for "VANGL2 Antibody - N-terminal region (OAAB15535)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "VANGL2 Antibody - N-terminal region (OAAB15535)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "VANGL2 Antibody - N-terminal region (OAAB15535)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "59714 Da".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "VANGL2 Antibody - N-terminal region (OAAB15535)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "VANGL2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "VANGL2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "VANGL2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "VANGL2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "VANGL2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "VANGL2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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