UBE2D2 Antibody (OAAB19806)

Catalog No: OAAB19806

Size:100ul

All lanes: Anti-UBE2D2 Antibody at 1: 1000 dilution
Lane 1: Hela whole cell lysates
Lane 2: HepG2 whole cell lysates
Lysates/proteins at 20 ug per lane.
Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution
Predicted band size: 17 kDa
Blocking/Dilution buffer: 5% NFDM/TBST.

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB, IP
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Application Info: WB: 1:1000
• Reference: Jensen J.P.,et al.J. Biol. Chem. 270:30408-30414(1995).
  Rolfe M.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:3264-3268(1995).
  Guinn B.-A.,et al.Biochem. Biophys. Res. Commun. 335:1293-1304(2005).
  Yin Y.,et al.Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
  Ota T.,et al.Nat. Genet. 36:40-45(2004).
  

Target Info

• Gene Symbol: UBE2D2
• Alias Symbols: UBC4, PUBC1, UBCH4, UBC4/5, UBCH5B, E2(17)KB2
• NCBI Gene Id: 7322
• Description of Target: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.
• Uniprot ID: P62837
• Molecular Weight: 17 kDa