- Description of Target:
- TYR is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. It catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
- Gene Symbol:
- Official Gene Full Name:
- Tyrosinase (oculocutaneous albinism IA)
- NCBI Gene Id:
- Alias Symbols:
- OCA1A, OCAIA, CMM8, SHEP3
- Tissue Tool:
- Find tissues and cell lines supported by DNA array analysis to express TYR.
- RNA Seq:
- Find tissues and cell lines supported by RNA-seq analysis to express TYR.
- Swissprot Id:
- Protein Accession #:
- Nucleotide Accession #:
- Protein Name:
- Protein Size (# AA):
- Molecular Weight:
- Protein Interactions:
- SYVN1; UBC; TYRP1; RB1;
- The immunogen is a synthetic peptide directed towards the middle region of human TYR
- Product Format:
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
- Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
- Protein A purified
- Complete computational species homology data:
- Anti-TYR (ARP44269_T100)
- Predicted Homology Based on Immunogen Sequence:
- Cow: 86%; Dog: 100%; Goat: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%; Sheep: 100%; Zebrafish: 83%
- Species Reactivity:
- Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Sheep, Zebrafish
- Datasheets / Downloads:
- Printable datasheet for anti-TYR (ARP44269_T100) antibody
- Peptide Sequence:
- Synthetic peptide located within the following region: CLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQSSMHNALHIYM
- Blocking Peptide:
- For anti-TYR (ARP44269_T100) antibody is Catalog # AAP44269 (Previous Catalog # AAPP25649)
- Target Reference:
- Bidinost,C., (2006) Invest. Ophthalmol. Vis. Sci. 47 (4), 1486-1490
- Reconstitution and Storage:
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Aviva Systems Biology is the original manufacturer of this TYR antibody (ARP44269_T100)
Click here to view the TYR antibody Western Blot Protocol
Product Datasheet Link: TYR antibody (ARP44269_T100)
WB Suggested Anti-TYR Antibody Titration: 1.25ug/ml
Positive Control: Jurkat
Western Blot image:
Description of Target: TYR is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. It catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
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