TRAPPC2 Antibody - middle region (ARP50568_P050)

Catalog No: ARP50568_P050

WB Suggested Anti-TRAPPC2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:12500
Positive Control: Human Spleen

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TRAPPC2
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 100%
• Peptide Sequence: Synthetic peptide located within the following region: RQEDGIKNFFTDVYDLYIKFSMNPFYEPNSPIRSSAFDRKVQFLGKKHLL
• Concentration: 0.5 mg/ml
• Blocking Peptide: Catalog # AAP50568 (Previous Catalog # AAPP13941)
• Subunit: 2
• Reference: Ross,M.T., (2005) Nature 434 (7031), 325-337

Target Info

• Gene Symbol: TRAPPC2
• Gene Full Name: Trafficking protein particle complex 2
• Alias Symbols: SEDL, SEDT, MIP2A, TRS20, ZNF547L, hYP38334, TRAPPC2P1
• NCBI Gene Id: 6399
• Description of Target: TRAPPC2 prevents MBP1-mediated transcriptional repression and antagonizes MBP1-mediated cell death. TRAPPC2 may play a role in vesicular transport from endoplasmic reticulum to Golgi.The protein encoded by this gene is thought to be part of a large multisubunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind MBP1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseuodogenes are found on chromosomes 8 and Y. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been found for this gene.
• Uniprot ID: O14582
• Protein Accession #: NP_055378
• Nucleotide Accession #: NM_014563
• Protein Size (# AA): 140
• Molecular Weight: 16kDa
• Protein Interactions: TRAPPC3L; TRAPPC5; TRAPPC6B; TRAPPC9; TRAPPC6A; TRAPPC11; TRAPPC4; TRAPPC12; TRAPPC3; TRAPPC8; TRAPPC10; ELAVL1; UBC; JOSD2; CLIC1; CLIC2; ENO1;